So, guys, Derek, more plates,merdates.com.

Today we're going to be talking about testosterone replacement therapy, TRT, and the risks.

This is something that obviously is a concern for a lot of individuals who are on testosterone,

not just super physiological dosages.

Guys on TRT, you have to keep in mind, when you're not functioning with a diurnal

rhythm of endogenous testosterone secretion, you are basically redlining your system a little

bit. You are chronically maintaining a stable level of super high, you know, depending on, you know,

how much you're pushing your TRT. You know, most people are going to push it you know it's a high normal high perpetual androgenic signaling which may put your body

in an increased state of sympathetic drive you know perpetually may cause you know

androgenic signaling and exposure in your brain in your heart in your other organ systems

all perpetually around the clock

without a break or a dip like you would normally get with your classical endogenous,

diurnal rhythm, pulsatile secretions that you otherwise would function with as a natural. And again,

binding protein production gets driven down a little bit too when you're using exogenous testosterone

in reasonable dosages. You're going to have a lower SHBG bit too when you're using exogenous testosterone in reasonable dosages.

You're going to have a lower SHBG in general when you're on exogenous TRT, especially at the dosages

most guys are using TRT at and the way they're administering it with the relatively infrequent administrations,

driving SHBG a little bit down for some guys borderline into the ground and raising their free testosterone

levels disproportionately to that of essentially super physiological territory. So they're walking

around with I don't know like 600, 700, 800 totals and then disproportionately high freeze.

And they're maintaining this level like perpetually around the clock.

Now, is somebody like that, like obviously that's a situation.

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