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Something You Should Know

Why You Hate Uncertainty & The New Science of Living Longer

Something You Should Know

Mike Carruthers | OmniCastMedia

Education, Self-improvement, Health & Fitness, Social Sciences, Science

4.54.3K Ratings

🗓️ 11 May 2026

⏱️ 47 minutes

🧾️ Download transcript

Summary

Have you ever struggled with a problem—only to have the answer suddenly appear when you stopped trying? It feels almost like magic, but it’s actually your brain working in a very specific way when you step back. https://drexel.edu/now/archive/2016/March/Insight_Correctness/ We all want to know what’s going to happen next. But life doesn’t work that way. In fact, the real challenge may not be uncertainty itself—but our growing discomfort with it. Simone Stolzoff, journalist and author of How to Not Know: The Value of Uncertainty in a World that Demands Answers (https://amzn.to/428rpWb), explains why we crave certainty, why that craving can make life harder, and how learning to tolerate—and even embrace—uncertainty can change the way you experience the world. You’ve probably heard that your health is shaped by both your genes and your lifestyle. But how much control do you really have? Are some outcomes unavoidable—or can your daily choices actually override genetic risk? Dr. Florence Comite, endocrinologist and expert in longevity and precision medicine, has spent decades studying how to optimize health at the individual level. In our conversation, she explains how genes influence your future, where they don’t, and how understanding your personal biology can help you make smarter decisions to improve health and extend lifespan. She is author of Invincible: Defy Your Genetic Destiny to Live Better, Longer (https://amzn.to/3Pir404). In the middle of a tense conversation, it’s easy for things to escalate quickly. But there’s a simple three-word phrase that can instantly shift the tone—turning conflict into something more productive and less combative. Source: Bill Jensen author of The Simplicity Survival Handbook (https://amzn.to/4thwWEX) PLEASE SUPPORT OUR SPONSORS AQUA TRU: Take the guesswork out of pure, great-tasting water. Head to ⁠⁠https://AquaTru.com⁠⁠ now and get 20% off your purifier using promo code SYSK. AquaTru even comes with a 30-day best-tasting water guarantee or your money back. RULA: This Mental Health Awareness Month, don’t just think about your mental health - actually take the step to take care of it. Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://Rula.com/sysk⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to get started. QUINCE: Refresh your everyday with luxury you will actual use! Go to ⁠⁠⁠⁠https://Quince.com/sysk⁠⁠⁠⁠ for free shipping on your order and 365-day returns. Now available in Canada, too! SHOPIFY: It's time to turn those "what ifs" into CHA CHING with Shopify Today! Sign up for your $1 per month trail and start selling today at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://Shopify.com/sysk⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

Click on a timestamp to play from that location

0:00.0

Today, on Something You Should Know, have you ever had the solution to a problem just pop in your head?

0:08.7

I'll explain why that happens.

0:11.0

And uncertainty.

0:12.9

Humans have never handled uncertainty very well.

0:17.0

You pair that with a more modern phenomenon, the decrease in our tolerance of uncertainty.

0:22.6

With the rise of the internet, we have this increasing expectation that answers should be readily available,

0:28.6

and an increasing discomfort with not knowing.

0:31.6

Also, a simple phrase that will ease the tension in any conversation,

0:36.6

and a leading endocrinologist on the good

0:39.8

news about living longer. There are more and more people we know for a fact that are living beyond

0:45.8

100. I do think 120 is possible in our lifetime. And the way to do that is not how to worry about longevity, but rather the quality

0:56.2

of your life. All this today on something you should know. Ready to launch your business? Get started

1:03.3

with the commerce platform made for entrepreneurs. Shopify is specially designed to help you start,

1:08.5

run and grow your business with easy customizable themes

1:11.9

that let you build your brand, marketing tools that get your products out there. Integrated shipping

1:16.5

solutions that actually save you time, from startups to scaleups, online, in person and on the go.

1:23.1

Shopify is made for entrepreneurs like you. Sign up for your $1 a month trial at Shopify.com slash setup.

1:32.0

Something you should know.

1:33.8

Fascinating Intel, the world's top experts,

1:37.2

and practical advice you can use in your life.

1:40.5

Today, something you should know with Mike Carruthers.

1:52.0

Have you ever had an answer to a problem or a solution to something you've been thinking about? It just pops in your head out of nowhere.

...

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