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Dr. Joseph Mercola - Take Control of Your Health

Why Is Migraine More Common in Women Than Men?

Dr. Joseph Mercola - Take Control of Your Health

Briana Mercola

Health & Fitness, Alternative Health

4.61.5K Ratings

🗓️ 18 December 2025

⏱️ 8 minutes

🧾️ Download transcript

Summary

  • Migraines affect women three to four times more often than men, largely due to hormonal fluctuations that sensitize the brain's pain pathways and increase vulnerability to stress, poor sleep, and inflammation
  • Estrogen both primes and triggers migraine attacks — high levels heighten sensitivity, while sudden drops before menstruation or after childbirth cause the electrical instability that sparks pain
  • Natural progesterone helps counteract estrogen's pro-inflammatory effects, calming nerve excitability and reducing migraine frequency during hormonally active years
  • Mitochondrial dysfunction is a major driver of migraines; reducing linoleic acid from seed oils and restoring nutrients like magnesium, CoQ10, and B vitamins strengthens your brain's energy supply and resilience
  • Supporting melatonin through morning sunlight, minimizing blue light exposure at night, and maintaining oral and circadian health naturally lowers inflammation, helping prevent migraines and improve overall brain function

Transcript

Click on a timestamp to play from that location

0:00.0

What if the headache that knocks you out for a day is actually a signal that your hormones and cellular energy are out of sync,

0:06.0

and you can track the pattern before the next attack?

0:09.0

Welcome to Dr. Mercola's cellular wisdom.

0:12.0

Stay informed with quick, easy-to-listen summaries of our latest articles, perfect for when you're on the go.

0:17.0

No reading required. Subscribe for free at mercola.com for the latest health

0:21.9

insights. Hello and welcome to Dr. Mercola's cellular wisdom. I'm Ethan Foster, and today we're

0:28.9

exploring why women experience migraines three to four times more often than men, how estrogen and

0:35.2

progesterone shape your sensitivity to pain, and what you can do to support

0:39.4

mitochondrial function, so attacks become less frequent and less intense.

0:44.0

I'm Alara Sky. We'll keep this focused on what the research shows, how hormone fluctuations prime

0:50.1

and trigger migraines, why mitochondrial health matters, and practical steps you can take,

0:56.0

like lowering linoleic acid, supporting melatonin, rebuilding key nutrients, improving oral health,

1:03.0

and tracking personal triggers.

1:04.9

Let's start with the gender gap.

1:07.2

You're more likely to face migraines during hormonally active years, and the reason is straightforward.

1:12.5

Estrogen both heightens sensitivity and, when it drops suddenly, triggers electrical instability in your brain.

1:19.0

That's the sequence behind the pain, light, and sound sensitivity, and sometimes dizziness or nausea.

1:26.0

You can think of high estrogen as a priming step that turns up the volume on your pain pathways.

1:31.3

Then the rapid decline before menstruation or after childbirth becomes the spark that sets off the attack.

1:39.3

Natural progesterone provides a counterbalance by calming nerve excitability,

1:43.3

which is one reason patterns

1:45.2

often shift across pregnancy and perimenopause.

...

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