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Freakonomics, M.D.

Why Don’t We Have a Cure for Alzheimer’s? (Ep. 49 Update)

Freakonomics, M.D.

Freakonomics Radio + Stitcher

Society & Culture, Science

4.81.1K Ratings

🗓️ 25 November 2022

⏱️ 33 minutes

🧾️ Download transcript

Summary

Promising drugs keep failing in trials. Allegations of fraud have cast a shadow over the field. An expert explains why Alzheimer’s treatments have been so hard to find — and why one clue may lie in the Andes Mountains.

Transcript

Click on a timestamp to play from that location

0:00.0

A few months ago, I spoke with Dr. Pierre Terrio, a leading Alzheimer's disease researcher.

0:10.3

We talked about some new research on Alzheimer's and why we still don't have a cure.

0:16.0

That episode came out over the summer and since then, there have been some exciting

0:20.4

updates in the field.

0:22.3

Make sure to stick around and I'll tell you about those developments as well as a new

0:26.0

research idea at the end of the episode.

0:29.2

One more thing, since you might catch this episode over Thanksgiving weekend, it made

0:33.9

me think of some clever research published a few years ago in the journal Science.

0:39.6

Using geolocated mobile phone data that allowed researchers to study when different people's

0:44.8

phones were near each other, they found that in 2016, families with different political

0:50.8

leanings spent less time together over Thanksgiving.

0:55.2

In that election year, Americans lost almost 75 million hours of family time as a result

1:01.8

of these differences.

1:03.5

Politics aside, I hope that everyone enjoys Thanksgiving with their friends and family

1:08.2

and that you also enjoy today's episode, which we called, Why Don't We Have A Cure for

1:13.8

Alzheimer's?

1:23.6

In 1906, Dr. Aloy's Alzheimer spoke of a female patient with quote, an unusual disease

1:30.4

of the cerebral cortex.

1:32.6

Her symptoms included memory loss, disorientation, and hallucinations.

1:38.7

After she died at age 50, an autopsy revealed that her cerebral cortex was unusually thin

1:45.0

and contained what are now known as amyloid plaques, which previously had only been observed

1:50.9

in elderly people.

...

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