Why Doctors Can't Fix Women in 2026 : 1446
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
4.6 • 7.4K Ratings
🗓️ 9 April 2026
⏱️ 79 minutes
🧾️ Download transcript
Summary
Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.
Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Dr. Sarah Daccarett, MD, a physician, longevity expert, and the founder and CEO of Inner Balance, a modern women's health company redefining hormone therapy, sexual wellness, and aging. She has treated tens of thousands of women across all 50 states and is known for challenging outdated medical models and building science-driven solutions that reflect female biology rather than borrowing protocols designed for men. She created Oestra, a revolutionary hormone therapy delivery system, along with Libida, an on-demand libido solution that targets desire at the brain level, making her one of the most credible and innovative voices in functional medicine and women's longevity today.
Together, they expose why conventional medicine has failed women for decades, why patches and pills are nearly useless, and what actually works for anti-aging, metabolism, longevity, and human performance. Dr. Sarah makes the case that hormone replacement therapy is not a last resort for menopausal women. It is a foundational longevity strategy that every woman should consider starting in her 20s.
You'll Learn:
- Why vaginal hormone delivery outperforms every other delivery method for women
- How low estrogen destroys your gut lining, gallbladder, and immune system long before menopause symptoms appear
- Why a carnivore or animal-based diet raises estrogen and why fiber lowers it
- How progesterone converts to testosterone in women, and why you may not need a testosterone prescription
- The real reason SSRIs get prescribed when hormone replacement therapy should come first
- Why iodine is essential for breast health, estrogen metabolism, and thyroid function
- How oxalates from "superfoods" like matcha, spinach, and almonds accumulate in your ovaries, uterus, and kidneys
- Why both partners need hormone replacement therapy for a relationship to thrive
- How hormones control mitochondria, dopamine, norepinephrine, and every system in your body
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Dr. Sarah Daccarett, Inner Balance, women's hormone therapy, bioidentical hormones, vaginal hormone delivery, estrogen deficiency, progesterone therapy, hormone replacement therapy, perimenopause, testosterone women, COMT genetics, FSH hormone, iodine deficiency, oxalates health, leaky gut hormones, women's longevity, biohacking, Dave Asprey, human performance, functional medicine, anti-aging
Resources:
• Visit Sarah’s Website and use code ‘PODCASTDRSARAH’: https://www.innerbalance.com/
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• Upgrade Labs: https://upgradelabs.com
Timestamps:
0:00 – Trailer
1:15 – Introduction
2:43 – The Gender Gap in Hormone Care
5:14 – Why Women's Hormone Therapy Is Stuck in the 1960s
8:09 – Why Young Women Are Losing Their Hormones
9:33 – Toxins, Birth Control & Hormone Disruption
14:07 – How Fiber Steals Your Hormones
19:53 – Hormones, Libido & Brain Chemistry
32:13 – Pills, Patches & Why They Fail
36:54 – Why Vaginal Delivery Works Best
44:36 – Symptoms of Low Hormones
46:07 – Leaky Gut Is a Hormone Problem
47:38 – How Low Hormones Destroy Relationships
52:28 – Thyroid, Iodine & Sex Hormones
1:00:29 – Progesterone for Men
1:05:18 – Oxalates, Kidney Stones & Your Diet
1:11:13 – Where to Find Dr. Sarah
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Transcript
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| 0:00.0 | What percent of divorces are caused by low hormones? |
| 0:03.0 | It's a lot. |
| 0:04.0 | I've had clients come and sit in my office and say that it's starting to impact their relationship and they know it. My husband doesn't irritate me anymore. There's just such this baseline irritation, you know, like that they couldn't stand him anymore. And then they got on the hormones and they're like, he's fine. He's just like, you know what I mean? Like it's not him. If you've reached in a relationship, like it kind of applies to like a stable equally brim, |
| 0:23.6 | where you're both, eh, you know, we're kind of roommates and like things are good. And then one of the two is like, I will eat you alive. It's not going to end well. It's actually a problem that we don't recognize enough. and then we treat men with Viagra and, you know, |
| 0:35.5 | testosterone too, we're not treating women. |
| 0:37.0 | And so we're studying the relationship up for turmoil. |
| 0:39.5 | I recommend with 100% certainty if one partner, you have to put the other one on. Because otherwise, if you've reached in a relationship, that passion, yeah, libido is a part of that, but libido is also, it's Chi, it's life force energy. And if you're not feeling that, maybe fixing your hormones |
| 0:54.2 | and your mitochondria might be worth doing. |
| 1:11.2 | And then we change how they're getting it. And it's like watching when you water a plant that needs watered, like it just comes to life. You put a small amount of testosterone around on the clit. And you'll see blood flow like you've never seen before. And if you get the big things right, like hormones, it unlocks just a level of power. |
| 1:11.2 | You're listening to The Human Upgrade with before. And if you get the big things right, like hormones, it unlocks just a level of power. |
| 1:15.6 | You're listening to The Human Upgrade with Dave Asprey. |
| 1:24.5 | There's a youth molecule in all your cells that you're losing every year. It's NAD plus. It repairs your DNA and supports your mitochondria, helps your body convert food into usable energy. It keeps your metabolism running. It helps you regulate inflammation. And if you want to live a long time, you're going to need it. But by the time you reach your 40s, your NAD plus levels are about half what they were when you're age 20. That's if you're even healthy when you're 20. The good news is that you can take supplements that raise your NAD plus levels. Bad news is that a lot of them don't work. And for something as |
| 1:49.2 | important as my NAD plus levels, I don't want to hope a supplement works. I want to know it does. |
| 1:54.4 | Some supplements have nothing supporting their claims. Others do a little better with studies |
| 1:58.8 | on just ingredients in their product. But the gold |
| 2:01.1 | standard is when a company runs a clinical study on the product itself. Did you know out of 90,000 |
| 2:06.8 | supplement products, only about 100 are clinically proven? Qualia NAD plus is one of those. In multiple |
| 2:12.5 | double-blind placebo-controlled studies, it increased NAD plus levels by 67%. So if you want to take the guesswork |
| 2:18.9 | out of maintaining high NAD plus levels as the age, go to qualiaLife.com slash Dave NAD, and they'll |
| 2:25.4 | give you a 15% off at checkout. They also have a 100-day money-back guarantee, so what do you have to lose? |
| 2:30.3 | That's qualialife.com slash Dave NAD. Did you know that erections can be a biomarker for more than sex? |
| 2:37.6 | Your circulation controls performance everywhere. |
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