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TED Health

Why building new proteins from scratch is our new superpower | David Baker

TED Health

TED

Shoshana Ungerleider, Ted Shoshana, Ted Talks Health, Health & Fitness, How To Be Healthier, Medicine, Fitness

4.01.5K Ratings

🗓️ 27 January 2026

⏱️ 29 minutes

🧾️ Download transcript

Summary

The rapidly evolving field of protein design is revealing solutions to some of the world’s greatest problems, whether it's blocking a virus, breaking down a pollutant or creating brand-new materials. In conversation with TED’s Whitney Pennington Rodgers, biochemist David Baker explores his team’s Nobel Prize-winning work using AI to design new proteins with functions never before seen in nature — achieving breakthroughs that have fundamentally changed the future of science. (This conversation was part of an exclusive TED Membership event. TED Membership is the best way to support and engage with the big ideas you love from TED. To learn more, visit ted.com/membership.)



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Transcript

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0:00.0

This is Ted Health, a podcast from Ted, and I'm your host, Dr. Shoshana Ungerleiter.

0:06.2

We're a month into the new year now, that window where resolutions are still fresh,

0:11.3

but reality is started to settle back in. It's actually the perfect time for reflection.

0:17.1

We've had enough distance from the holidays to see things clearly, but we're still early

0:21.2

enough in the year to shape what comes next.

0:24.6

In health and science, that sense of possibility feels especially alive right now.

0:29.7

We're entering this new year with new tools, new ideas, and even new ways of understanding

0:34.8

the human body and the world we live in. So let's jump in.

0:39.5

As we think about what we'll create and build this year, I think it's also fitting to dig

0:43.7

into the building blocks of life. When I say that, you might picture DNA, that famous double

0:49.7

helix we all learned about in biology class. But here's the thing. DNA is really just the instruction

0:56.1

manual. Proteins are where the actual work happens. They're the molecular machines running

1:02.1

everything in your body right now, fighting off infections, repairing tissue, carrying oxygen

1:08.4

through your blood, sending signals between your cells.

1:11.6

Every single function that keeps you alive depends on proteins doing their jobs with extraordinary precision.

1:18.6

For billions of years, nature has been the only architect of these molecules.

1:22.6

The idea of designing new proteins from scratch, proteins that never existed anywhere in the natural

1:28.7

world, seemed almost impossible, until biochemist Dr. David Baker figured out how to do exactly that.

1:36.9

He's been part of the work that's moved us beyond reading Nature's playbook.

1:40.9

Now we're writing new chapters, and the implications are staggering. We're talking about

1:46.6

designing proteins that could block deadly viruses before they infect us. Proteins that can

1:52.6

break down plastics choking our oceans, or help crops survive in a warming climate. This work earned

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