Who visits raccoon latrines, and boosting cancer therapy with gut microbes

Science Magazine Podcast

Science Podcast

News, News Commentary, Science

4.3 • 842 Ratings

🗓️ 4 January 2018

⏱️ 18 minutes

🔗️ Recording | iTunes | RSS

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Summary

David Grimm—online news editor for Science—talks with Sarah Crespi about a long-term project monitoring raccoon latrines in California. What influence do these wild bathrooms have on the ecosystem? Sarah also interviews Christian Jobin of the University of Florida in Gainesville about his Perspective on three papers linking the success of cancer immunotherapy with microbes in the gut—it turns out which bacteria live in a cancer patient’s intestines can predict their response to this cutting-edge cancer treatment. Read the related papers: Routy et al., Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors, Science 2018 Gopalakrishnan et al., Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018 Matson et al., The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients, Science 2018 aan4236 Listen to previous podcasts. [Image: cuatrok77/Flickr; Music: Jeffrey Cook] Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	This podcast is supported by the Icon School of Medicine at Mount Sinai,
0:04.0	the academic arm of the Mount Sinai health system in New York City,
0:07.5	and one of America's leading research medical schools.
0:10.7	What are scientists and clinicians working on to improve medical care and health for women?
0:15.5	Find out in a special supplement to Science magazine prepared by the Icon School of Medicine
0:20.0	and Mount Sinai in partnership
0:21.6	with science. Visit our website at www.science.org and search for Frontiers of Medical
0:27.5	Research-Wedmen's Health. The Icon School of Medicine at Mount Sinai, we find a way.
0:43.0	Welcome to the Science Podcast for January 5th, 2018.
0:44.4	I'm Sarah Crespi.
0:49.1	In this week's show, David Grimm talks raccoon latrines.
0:55.4	Why would anyone or anything visit these masked bandit bathrooms? And Christian Joban talks with us about three papers published this week in science that
1:01.2	connect cancer immunotherapy and the gut microbiome.
1:06.3	What do our intestinal bugs have to do with fighting cancer.
1:19.2	Now we have David Grimm, editor for our daily news site. He's here to talk about a recent online story. Welcome, Dave.
1:21.1	Hey, sir. Okay, we're going to talk about raccoon latrines today, Dave. Let's start with the
1:26.0	concept of latrines. This is a place where an animal
1:29.9	goes the bathroom repeatedly. What are some of the reasons certain species might do this?
1:35.7	You know, we know that a lot of animals do this. We know ocelots do this and they all poop in the
1:40.4	same place and it sort of becomes a hots spot for biodiversity. This case is sort of
1:45.8	a little bit different, almost kind of the opposite. These are raccoons. They like to poop also
1:50.2	a lot in the same place on top of logs, on top of prominent hills at the basis of boulders.
	...

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