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Lifespan with Dr. David Sinclair

What To Do For Longevity | Lifespan with Dr. David Sinclair Rewind

Lifespan with Dr. David Sinclair

Lifespan Communications LLC

Health & Fitness

4.94.9K Ratings

🗓️ 6 May 2026

⏱️ 59 minutes

🧾️ Download transcript

Summary

What are the most important things you can do today to live longer and stay healthier while doing it? In this first Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most impactful insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application. This episode covers: What to eat – and what to avoid – for long-term health How to think about exercise for longevity (not just performance) The role of cold and heat exposure Which supplements may support healthy aging Emerging medical interventions and what the science actually shows The tools and protocols Dr. Sinclair personally uses in his own routine Whether you're new to longevity science or looking to refine your approach, this episode brings together the most important principles in one place so you can better understand not just what to do, but why it matters. At Lifespan, our mission is to help you and your loved ones live longer, healthier lives while supporting medical research aimed at breakthroughs to extend all our lives. Join us at: https://lifespan.com. We’re building the world’s largest longevity community who will grow, learn, and live longer together.  Subscribe here for new Lifespan show episodes every two weeks.                                __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in strong science – and products our team has personally used for many years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode – from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat content and muscle gains (Withings). If you’d like to learn more or try these tools: Ketone-IQ: Get 30% off your first monthly order at ketone.com/lifespan with code LIFESPAN WHOOP: Get a free WHOOP band plus one month free at join.whoop.com/LIFESPAN with code LIFESPAN Withings: Explore their smart health devices at withings.com/lifespan using code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

Transcript

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0:00.0

Welcome to Lifespan, a show where we discuss the cutting-edge science of aging and how to live healthier at any stage of life.

0:10.0

I'm David Sinclair, a scientist and professor working on understanding why we age and discovering new ways to slow and even reverse the aging process. On this show, I share an insider's look at the latest from my lab, the field, and what's just around the corner.

0:33.6

When we launched Lifespan Season 1, it was intended as an eight-episode experiment

0:41.5

to explore whether there was demand for understanding the science of aging

0:45.6

and how to apply it in everyday life.

0:48.5

What happened next surprised me.

0:50.7

The show became the number one ranked Health and Fitness podcast

0:53.5

and helped spark a global

0:55.4

interest in longevity science. Since then, while I've been running my lab to understand how

1:00.4

age reversal works and getting the first age reversal drug into humans, almost every day someone

1:06.1

has asked me, when is season two coming? Now that both those endeavors are on track, I'm bringing

1:11.8

lifespan back for season two. We're kicking things off with two special rewind episodes.

1:17.6

This one is about how to live longer and healthier, featuring some of the most important

1:21.8

and unexpected insights from season one. From what to do and what to avoid for a longer,

1:27.1

healthier life, to some of the most surprising discoveries to do and what to avoid for a longer healthier life to some of the most

1:28.8

surprising discoveries about aging and what affects it. Longevity is driven by daily habits,

1:34.9

not complexity, just consistency, and I'm going to guide you through it. Even if you watch

1:40.6

season one, go watch these rewinds I have. It's very relevant to our lives today and we'll prepare you watch season one, go watch these rewinds, I have.

1:47.9

It's very relevant to our lives today and we'll prepare you for season two.

1:52.1

Importantly, every insight meets Lifespan's rigorous scientific standards,

1:57.3

meaning the science we're revisiting remains as true today as it was at the time of recording.

2:00.2

This show is actually part of something much bigger. I'm launching Lifespan,

...

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