What if Your Brain Isn’t Broken—It’s Just NAD Depleted? A Deep Dive into NAD Supplements with Guest Dr. Andrew Salzman of Wonderfeel
The Dr. Leaf Show
Dr. Caroline Leaf
4.6 • 3.2K Ratings
🗓️ 10 September 2025
⏱️ 38 minutes
🧾️ Download transcript
Summary
Brain fog, anxiety, and mental decline are often treated like inevitable parts of aging. But what if that narrative is wrong?
In this episode, I’m joined by Harvard-trained physician and NAD expert Dr. Andrew Salzman, Chief Medical Officer at Wonderfeel, to explore the science of brain aging—and why your brain’s “fuel supply” matters more than you think.
We’ll unpack:
✅ Why cognitive decline isn’t inevitable
✅ How one molecule (NAD+) drives 500+ critical cellular functions
✅ Why NAD levels plunge by 50% by midlife—and what that means for brain health
✅ The surprising role of CD38 in accelerating aging
✅ Real-life benefits of NMN supplementation for energy, focus, and recovery
✅ How the Wonderfeel Youngr™ NMN formula is designed to protect NAD and support healthy aging
This conversation is about proactive longevity—not just adding years to life, but life to your years. Whether you’re 25 or 65, your brain needs energy to thrive.
🎧 Tune in now and learn how to keep your brain sharp, your memory strong, and your mind energized for decades to come.
👉 SPECIAL OFFER: Using the code DRLEAF gets you $15 off + $20 credit for your next order at getwonderfeel.com. The code is active for one week.
Wonderfeel Homepage: https://getwonderfeel.com/?utm_source=DrLeaf&utm_medium=podcast
Wonderfeel Youngr™ NMN Poduct Page: https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=DrLeaf&utm_medium=podcast
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Transcript
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| 0:00.0 | Dad, why can't we just print more money to buy new things? And will the bank of mum and dad |
| 0:06.2 | still be open when I'm older? Because children have questions about money. Help them find the |
| 0:11.7 | answers with a wealthify junior stocks and shares ISA. Voted best junior Icer at the personal |
| 0:16.5 | finance awards six years running. Open your little one's account at wealthify.com, helping them |
| 0:22.2 | become younger and wiser. The smart monies with wealthify. Capital at risk, wealthify is |
| 0:27.6 | authorized and regulated by the financial conduct authority. What if your brain isn't broken, |
| 0:34.5 | it's just depleted. The brain does not produce consciousness, but it makes it |
| 0:38.8 | possible for us to experience it. And for this reason alone, we do need to look after the brain. |
| 0:44.3 | In this episode, I'm going to challenge the narrative that brain fog, anxiety and mental |
| 0:48.7 | decline are inevitable. My expert guest today to discuss this with me is Dr. Salsman. Dr. Andrew Salsman is a Harvard |
| 0:55.9 | trained physician, biomedical entrepreneur and inventor with 30 years of experience in drug discovery |
| 1:02.0 | and development. He holds over 50 patents and is a globally recognized expert in inflammation, |
| 1:08.4 | cellular aging and NAD research. We're also going to explore how restoring |
| 1:13.0 | one molecule, NAD plus, can support the brain's natural power to heal, grow and stay sharp, |
| 1:19.5 | even as we age. Did you know that your natural ability to digest food declines with age? |
| 1:26.4 | This is because your body produces fewer enzymes, |
| 1:29.1 | which are the proteins responsible for digesting food. And fewer enzymes means, well, |
| 1:34.6 | more difficulty digesting food. Even healthy foods don't always provide enough enzymes to |
| 1:39.4 | properly digest them. The fact of the matter is that for many of us, our bodies just can't produce enough |
| 1:45.0 | enzymes to get the job done so that our brains and bodies can get all the nutrients we need. |
| 1:50.0 | This is where supplementing with a high-quality enzyme supplement can be a huge help. |
| 1:56.0 | I personally recommend mass asimes by bioptimizers. It's a best in-class supplement, loaded with full |
... |
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