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BrainStuff

What Happens When Your Immune System Turns on You?

BrainStuff

iHeartPodcasts

Science, Natural Sciences, Technology

3.91.7K Ratings

🗓️ 9 December 2025

⏱️ 13 minutes

🧾️ Download transcript

Summary

Your adaptive immune system remembers specific germs and fights them really effectively -- but it can sometimes make mistakes and attack your own healthy cells. Learn how the adaptive immune system works (and how it can go wrong) in this episode of BrainStuff.

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Transcript

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0:00.0

This is an I-Heart podcast.

0:02.5

Guaranteed Human.

0:05.8

Welcome to Brainstuff, a production of IHeart Radio.

0:10.7

Hey, Brainstuff, Lauren Boglebaum here.

0:14.4

You might think of your body sort of like a fabulous estate,

0:18.7

with a lot of different departments and individual workers that keep the

0:22.4

household running. For this metaphor, whether you want to imagine yourself as a medieval castle

0:27.9

or a countryside manor or more of a well-staffed but nonetheless haunted mansion is up to you.

0:35.4

You might say that you've got a kitchen staff in your digestive system because it

0:39.8

prepares nutrients for the whole household to use. Organs like your kidneys are part of the cleaning

0:45.1

staff. Your body also keeps a sharp security staff on hand in the form of your immune system.

0:52.5

There are two sub-departments or branches within the immune system,

0:56.0

the innate and the adaptive. A lot of germs that enter your body get dealt with with a swiftness

1:02.5

by your innate immune system. This is a whole organization of defenses that keep out and kick out

1:09.3

any sort of home invader, the home in this case being you.

1:13.7

Your innate immune system includes your skin and mucus membranes, which are physical barriers,

1:18.8

and some cells and enzymes that scan for, attack, and kill any germs that do make it in,

1:25.1

like in a state's physical walls, and its camera network and security

1:29.0

guards. The innate immune system is fairly automated and can't distinguish between different

1:35.0

types of invaders that well, but it's really effective at stopping them before they make you sick.

1:41.3

Unfortunately for us, some germs have evolved to evade our innate immune system.

1:46.8

When, for whatever reason, a germ survives in your body and keeps multiplying, the security guards of the innate immune system call into action that second branch, your adaptive immune system.

...

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