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The Brian Lehrer Show

What GLP-1s Know About Addiction

The Brian Lehrer Show

WNYC

Politics, News, News Commentary, Wnyc, Radio, Npr, Arts, New, Lerer, Media, Bryan, Nyc, Daily News, York, Public

4.61.5K Ratings

🗓️ 17 February 2026

⏱️ 21 minutes

🧾️ Download transcript

Summary

Dr. Dhruv Khullar talks about the effect GLP-1 drugs, like Ozempic, are having on curbing addictions and what researchers are studying about that phenomenon.

Transcript

Click on a timestamp to play from that location

0:00.0

Brian Laird on WNYC, OZempec, Wagovi, Mungaro. By now we've all heard of GLP-1

0:17.9

medications and the stunning impact they have on type 2 diabetes and obesity,

0:23.7

maybe you're on one. But researchers are looking into another possible use for this class of

0:28.8

drugs now, addiction treatment. While it's known that addiction is a medical disorder,

0:34.5

societally, it's often treated more like an indicator of one's morals or strength of will,

0:40.0

right? Untreated addiction often causes antisocial behavior, and when medical interventions fail,

0:46.9

compassion often runs dry. So could a medication revolutionize, not just how he treat addiction,

0:53.6

but also how he think about it. With me now to talk

0:56.5

about his latest piece in The New Yorker, Cano Zempecure Addiction, is Dr. Drew Kula, a practicing physician,

1:02.7

Associate Professor of Health Policy and Economics at Wilde Cornell Medical College, and contributing

1:08.1

writer at the New Yorker. Dr. Kularo is great to talk to you.

1:11.1

Welcome back to WNYC.

1:13.1

Thanks so much for having me.

1:14.5

There are a lot of names for this class of medications. We have the product names,

1:18.6

Ozampic Mujara, Mungara, etc. or the drug names, semaglutide, terzapeatide.

1:25.5

I'm sure I said that wrong. But they're all GLP-1s.

1:30.0

What is a, what is, what is, what is, what does GLP stand for?

1:34.2

Let's do that much of, you know, 101 and how it functions in the body.

1:39.4

Sure.

1:40.1

So, GLP-1s stand for glucagon-like peptide 1, and this has historically been associated with digestion.

1:47.6

And so we think about these medications or this molecule really, GLP-1, as attaching to receptors in the pancreas, in the stomach, in the brain.

1:57.0

And we've been thinking about it as something that, you know, helps release insulin and slows the

...

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