What Doctor's DON'T Tell You About Megadosing Creatine (Over 40) : 1447
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
4.6 • 7.4K Ratings
🗓️ 12 April 2026
⏱️ 34 minutes
🧾️ Download transcript
Summary
My favorite creatine (discount code DAVETUBE): https://www.qualialife.com/ASPREYRECOMMENDS
Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades.
Host Dave Asprey breaks down the myths and truths about creatine, uncovering how it enhances memory, supports your mitochondria, regulates mood, strengthens bones and heart function, and even aids fetal brain development during pregnancy. Drawing from decades of functional medicine, real-world biohacks, and new research featured in the Wall Street Journal, Dave explains how creatine works not only as a muscle booster but as a universal cellular fuel that supports brain benefits, memory improvement, and sleep optimization.
Timestamps:
0:00 – Introduction
1:14 – Why Creatine Matters
5:01 – History of Creatine
6:09 – Debunking the Myths
8:55 – 5 Ways Creatine Fuels Your Mind & Body
16:25 – How to Maximize Absorption
18:13 – Dosing: How Much & When to Take It
19:07 – Forms of Creatine Explained
19:50 – Special Use Cases
21:28 – Biohacking Real-World Applications
23:21 – What to Stack with Creatine
24:50 – Choosing the Right Creatine
28:40 – Recap & Key Takeaways
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Transcript
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| 0:00.0 | Want to know which foods and supplements work best for your body, Viom takes the guesswork out of it. |
| 0:05.3 | Their full body intelligence test reads your RNA, not your DNA, so you see what's happening |
| 0:11.8 | in your body right now. While standard labs measure around 100 markers, Viom's AI analyzes |
| 0:18.9 | over 10,000 active pathways across your gut, oral, and cellular health. |
| 0:24.7 | Then it translates that into personalized food and supplement recommendations built for your |
| 0:29.7 | unique biology. They'll tell you what foods to eat and which ones to avoid. They even create |
| 0:34.5 | custom supplements and oral care products based on your results. So what you're |
| 0:39.1 | getting is what will work for your body, not someone else's. Your results update as your lifestyle changes, |
| 0:45.5 | so your plan evolves with you. Check it out at viome.com and use code 10-d-A-V-E for 10% off. |
| 0:54.8 | It's time to stop guessing and start knowing your body. |
| 0:59.1 | Creatine wrecks your kidneys. |
| 1:00.7 | Creotene. |
| 1:01.3 | Creatine. |
| 1:01.6 | Creotene. |
| 1:02.1 | Creotene. |
| 1:03.0 | Creatine. |
| 1:04.0 | But there are now two decades of research in healthy adults that say up to 10 grams a day has no adverse kidney effects. |
| 1:16.6 | New attention on creatine to supplement bodybuilders made famous in that is now all the rage. After a new article in the Wall Street Journal says it could be key for improving your health and longevity. |
| 1:21.6 | Creatine is not a stimulant like caffeine at all. |
| 1:24.6 | Your body naturally makes about one gram of creatine per day in your liver, |
| 1:28.6 | your kidneys, and your pancreas. So it's a naturally occurring compound that's made up of |
| 1:32.5 | three different amino acids. Our body actually makes about a gram of it per day from our |
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