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The Clay Travis and Buck Sexton Show

Wellness Unmasked: Psychedelic Therapy Breakthrough? Trump’s New Mental Health Order, PTSD Crisis & Big Pharma Limits

The Clay Travis and Buck Sexton Show

iHeartPodcasts

Politics, News, Society & Culture, News Commentary, Daily News

4.511.4K Ratings

🗓️ 21 April 2026

⏱️ 22 minutes

🧾️ Download transcript

Summary

On this episode of Wellness Unmasked, Dr. Nicole Saphier breaks down a major new development out of the White House: an executive order aimed at accelerating research into psychedelic therapies for mental health. What does this mean for patients struggling with treatment-resistant depression, PTSD, and addiction? And could substances like psilocybin, MDMA, and ibogaine represent the next frontier in medicine—or a risky leap too far?

Transcript

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0:00.0

This is an I-Heart podcast.

0:02.6

Guaranteed Human.

0:08.1

Welcome to Wellness and Mass.

0:09.6

I'm Dr. Nicole Sapphire, and I have an interesting topic to talk to you about today.

0:13.8

I'm not sure if you caught the press conference over the weekend,

0:16.6

but President Trump, straight from the Oval Office, was working on Saturday morning.

0:21.7

And he had a lot of people behind him, including Secretary Kennedy, FDA Commissioner McCarrie.

0:27.1

And he also had Joe Rogan behind him.

0:29.3

Now, what were they all doing in the Oval Office on a beautiful Saturday?

0:33.2

Well, it kind of felt like we were being transported back to the 1970s. Now, what do I mean by that?

0:39.2

Well, because they were talking about psychedelic medications. And this executive order is aimed

0:44.3

at accelerating research and access to medications like psilocybin, MDMA, LSD. I'm not sure if

0:52.2

you knew that, but yeah, we have been studying these for decades in how

0:56.0

that they may be able to help us with addiction and refractory cases of mental illness.

1:01.9

Now, one that's specifically getting a lot of attention right now from the Oval Office is Ibegin.

1:07.7

Ibogin is a little bit different than the others.

1:09.9

While most psychedelics that have been

1:12.1

studied, like psilocybin and MDMA, they primarily work through serotonin pathways, and they've been

1:19.3

used for depression, PTSD. Ibrahimagane has a much broader pharmacologic profile. Not only does it

1:26.0

interact with serotonin, but also opioid receptors and

1:29.6

dopamine receptors. So, well, before we can jump into what this executive order even does,

1:36.7

I want to take a step back for a minute because when we talk about mental health and the

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