Welcome back to the Real Life Pharmacology podcast.

Thanks so much for all the support, kind words.

The reviews, the ratings on Amazon have, or excuse me, on iTunes has simply been overwhelming.

I can't thank you guys enough.

So I'm going to continue to try to keep going, keep pumping out good information

that's really helpful for you guys in preparing for your N-Clax, naplex, pants, all sorts of different

board exams, USMLE, and so on and so forth. So it's hard to believe that I haven't done a podcast on Warfarin. I think we're over 30 episodes now. And I haven't touched Warfron, one of the hallmark medications for concerns, questions, and lots of drug interactions, all that good stuff. So that's what we're tackling today.

Mechanistically, warfarin inhibits vitamin K, epoxide reductase complex, also abbreviated VK ORC. And with this inhibition,

Warfarin is actually classified as a vitamin K antagonist.

I think that's a good way to remember, a little more simple way to remember it,

is it blocks the action of vitamin K.

Now, vitamin K is essential in the formation of clotting factors.

And this has always been a test question I've seen come up on pharmacology in different exams,

which clotting factors are inhibited by warfarin. And the primary clotting factors,

I remember them by the term snot S-N-O-T-7-9 the O is 10 and the T is 2 so 279 and 10 are the clotting factors that are primarily impacted by warfarin.

Brand names of warfarin.

Kumidin, jantiven, two good ones to remember there.

What's this drug used for?

So we're inhibiting factors.

We're thinning the blood.

We're going to use warfarin to prevent blood clots and prevent strokes, prevent dvTs, things of that nature.

Now, the side effect profile is really pretty simple, bleeding.

...