meta_pixel
Tapesearch Logo
Log in
Science Friday

Vaccine Process, Hubble Space Telescope Anniversary, Alchemy Of Us. April 24, 2020, Part 2

Science Friday

Science Friday and WNYC Studios

Natural Sciences, Wnyc, Science, Friday, Life Sciences

4.4 • 6.3K Ratings

🗓️ 24 April 2020

⏱️ 49 minutes

🧾️ Download transcript

Summary

Over 50 pharmaceutical companies and biotech firms around the world are now racing to develop vaccines for the coronavirus responsible for COVID-19. Anthony Fauci has said that it might be possible to develop a vaccine in as quickly as 12 to 18 months—but so far, researchers still don’t know which of several approaches might be most safe and effective. Paul Offit, head of the Vaccine Education Center at Children’s Hospital of Philadelphia, says that usually, the standard time to develop a new vaccine and move it through the multiple phases of clinical trials required for FDA approval is measured in years, not months—and despite the need, he worries that shortening the path to a vaccine means that developers will skip critical parts of the testing process.  He joins Ira to talk about the path to a vaccine, and how it might fit in with other parts of the coronavirus response, including community testing and the development of therapeutic drugs to treat patients with COVID-19. Think about the breathtaking images you’ve seen of space—swirling, multicolor galaxies, shining star clusters, and far-off planets. There’s a good chance these photos were taken by the Hubble Space Telescope, which was launched into space 30 years ago today.  Over these decades, Hubble has helped researchers better understand space mysteries, like black holes, warped space, exoplanets, and the expansion of the universe. While it had a rough beginning—it was deployed with a miscalibrated mirror—Hubble has long maintained its status as the premiere telescope.  Joining Ira to celebrate this anniversary is Dr. Jennifer Wiseman, senior project scientist for the Hubble Space Telescope in Greenbelt, Maryland. When you think about how the telephone was invented, you probably think of Alexander Graham Bell. But what about the people who made the telephone effortless to use? For example, you might not have heard of Almon Strowger, a Kansas City undertaker in the late 19th century, who feared he was losing business thanks to poorly connected phone calls—at that time, calls relied on women known as “hello girls,” who manually operated the switches. Strowger’s frustration led him to invent the automatic switching system, which led to modern telephones, transistors, and eventually, computers. His name, however, is still less well-known. Strowger’s story is one of dozens documented in The Alchemy of Us, a new book by materials scientist Ainissa Ramirez, who explores the way human foibles and flaws have shaped our inventions—and how those inventions have changed us. Take, for example, Ruth Belleville, the Englishwoman who literally sold time until accurate clocks were ubiquitous, a story Ramirez uses to describe how industrialization and industrialized time have shaped our sleep. Producer Christie Taylor talks to Ramirez about her unexpected stories of innovation in time, light, photography, and telecommunications—inventions that all helped shape modern culture.

Transcript

Click on a timestamp to play from that location

0:00.0

This is Science Friday. I'm Ira Flato. A bit later in the hour, a salute to the Hubble Space

0:05.4

Telescope, which launched 30 years ago today. Seems like yesterday, right? But first, a key part of

0:11.8

plans to return to normal post-pandemic life is the availability of a vaccine against the

0:18.0

coronavirus. Many drug companies and biotech firms have plunged into efforts

0:23.2

to rapidly develop and test potential vaccines. Experts such as Dr. Anthony Fauci say it may take

0:30.3

12 to 18 months to bring a working vaccine to market. But is that timeline overly optimistic? Is it real? What about it? And just where

0:39.6

does having a vaccine fit into our overall response to the coronavirus pandemic? Joining me now is

0:46.6

Dr. Paul Offutt, director of the Vaccine Education Center and an attending physician in the

0:52.3

Division of Infectious Diseases at Children's Hospital of Philadelphia.

0:56.9

Welcome back, Dr. Offutt.

0:58.8

Thank you, Ira. Good to be back.

1:00.7

First, walk us through the process of what needs to be done before a vaccine can be available.

1:07.0

What is the testing process, the research process? What goes on here?

1:10.1

Well, typically what's done is, and this is a virus that we just got in hand a few months ago, is you have to make a decision about how you want to make the vaccine. Do you want to take the virus and inactivated as the way that the polio vaccine or hepatitis A vaccine is made? Do you want to take a virus and weaken it the way the measles vaccine is made? Do you want to just take part of the virus, just one protein from the virus, which is the way

1:31.5

the hepatitis B vaccine is made? Or do you want to use a completely different strategy, like a genetic

1:36.3

strategy, DNA vaccine, messenger RNA vaccine? So once you've made that decision, then usually you do

1:42.1

extensive animal model studies, so-called proof of concept

1:45.4

studies, where you have an animal that, for example, get sick with this virus, and then you

1:49.7

try a variety of different strategies to see if you can protect them from getting sick.

1:54.2

With that, then you go into phase one, phase two trials, which are progressively larger

1:58.5

safety immunogenicity trials, remembering that you don't

2:02.2

really know exactly what immune response is protective yet. The only way really to know that

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Science Friday and WNYC Studios, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Science Friday and WNYC Studios and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.