Vaccine Process, Hubble Space Telescope Anniversary, Alchemy Of Us. April 24, 2020, Part 2
Science Friday
Science Friday and WNYC Studios
4.4 • 6.3K Ratings
🗓️ 24 April 2020
⏱️ 49 minutes
🔗️ Recording | iTunes | RSS
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| 0:00.0 | This is Science Friday. I'm Ira Flato. A bit later in the hour, a salute to the Hubble Space |
| 0:05.4 | Telescope, which launched 30 years ago today. Seems like yesterday, right? But first, a key part of |
| 0:11.8 | plans to return to normal post-pandemic life is the availability of a vaccine against the |
| 0:18.0 | coronavirus. Many drug companies and biotech firms have plunged into efforts |
| 0:23.2 | to rapidly develop and test potential vaccines. Experts such as Dr. Anthony Fauci say it may take |
| 0:30.3 | 12 to 18 months to bring a working vaccine to market. But is that timeline overly optimistic? Is it real? What about it? And just where |
| 0:39.6 | does having a vaccine fit into our overall response to the coronavirus pandemic? Joining me now is |
| 0:46.6 | Dr. Paul Offutt, director of the Vaccine Education Center and an attending physician in the |
| 0:52.3 | Division of Infectious Diseases at Children's Hospital of Philadelphia. |
| 0:56.9 | Welcome back, Dr. Offutt. |
| 0:58.8 | Thank you, Ira. Good to be back. |
| 1:00.7 | First, walk us through the process of what needs to be done before a vaccine can be available. |
| 1:07.0 | What is the testing process, the research process? What goes on here? |
| 1:10.1 | Well, typically what's done is, and this is a virus that we just got in hand a few months ago, is you have to make a decision about how you want to make the vaccine. Do you want to take the virus and inactivated as the way that the polio vaccine or hepatitis A vaccine is made? Do you want to take a virus and weaken it the way the measles vaccine is made? Do you want to just take part of the virus, just one protein from the virus, which is the way |
| 1:31.5 | the hepatitis B vaccine is made? Or do you want to use a completely different strategy, like a genetic |
| 1:36.3 | strategy, DNA vaccine, messenger RNA vaccine? So once you've made that decision, then usually you do |
| 1:42.1 | extensive animal model studies, so-called proof of concept |
| 1:45.4 | studies, where you have an animal that, for example, get sick with this virus, and then you |
| 1:49.7 | try a variety of different strategies to see if you can protect them from getting sick. |
| 1:54.2 | With that, then you go into phase one, phase two trials, which are progressively larger |
| 1:58.5 | safety immunogenicity trials, remembering that you don't |
| 2:02.2 | really know exactly what immune response is protective yet. The only way really to know that |
... |
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