Using Next-Generation Sequencing in the Search for Efficacious Vaccines—Irina Chelysheva—Oxford Vaccine Group
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 7 September 2020
⏱️ 30 minutes
🧾️ Download transcript
Summary
Postdoctoral researcher and medical bioinformatician, Irina Chelysheva, is a member of the Oxford Vaccine Group. Today, she discusses her work and knowledge regarding vaccine research and development.
Press play to discover:
- How the use of next-generation sequencing technology could be used for developing more efficacious vaccines
- How the transcriptome of a cell differs from the translatome of a cell, and what type of information is conferred by sequencing each
- What changes with age in terms of the immune response to vaccines (and why certain vaccinations are scheduled at very specific ages)
Chelysheva begins by shedding light on what it means to be a bioinformatician and the important role of bioinformatics in science and research. She also explains how next-generation sequencing can be applied to the area of vaccine research and development. For example, a person's human leukocyte antigen (HLA) system could play a role in how effectively a vaccine works for them.
Sequencing allows you to see the mutations, HLA, and gene expression by performing RNA/ transcriptome sequencing. It also allows you to distinguish between groups of people who have specific genes or pathways activated and groups of people who do not, which can have implications for how a person will react to a vaccine.
Chelysheva also talks about the normal immune response to vaccination and overreactions by the immune system in response to vaccination, and shares the details and findings of her work on vaccines and genetic sequencing. One of the main questions she aims to answer is why T cells might be produced by one organism but not another organism after vaccination. In addition, she discusses why some vaccines fail to work, why they are challenging to develop, her take on a COVID-19 vaccine, Oxford Nanopore Technologies, and more.
Check out https://www.ovg.ox.ac.uk/team/irina-chelysheva for more.
Available on Apple Podcasts: apple.co/2Os0myK
Transcript
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| 0:00.0 | Forget frequently asked questions common sense common knowledge or Google how about advice from a real genius |
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| 0:28.8 | Here come the geniuses. |
| 0:30.4 | This is the Finding Genius Podcast. |
| 0:33.0 | That is Richard Jacobs. |
| 0:35.0 | Hello, this is Richard Jacobs with the Finding Genius Podcast. |
| 0:41.0 | My guest, she's over in England. Her name is |
| 0:44.4 | Irina Shalishava. She's a postdoctoral researcher, medical |
| 0:48.8 | bioinformatician, part of the Oxford Vaccine Group. And she does what's called bioinformatics. |
| 0:55.0 | I'm going to have her define that. |
| 0:56.0 | And a lot of her work goes towards vaccine research |
| 1:00.0 | and understanding using next generation sequencing, which will also define, you know, how to find vaccines maybe faster and more efficacious ones. |
| 1:09.0 | So, Erino, thanks for coming. How you doing? |
| 1:11.0 | Thanks for having me. That's great, Richard. I'm looking forward to our |
| 1:14.7 | podcast. Okay so just to start two definitions what is bioinformatics and then I |
| 1:19.7 | want to talk about next-gen sequencing. What does that mean? |
| 1:23.1 | Okay, so basically the bianpharmacic is a kind of a novel part of the science which is |
| 1:28.9 | important to be defined as research because many people think that by informatics is a service. |
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