Urolithin A’s Secret to YOUTHFUL ENERGY and the Fight Against Inflammaging : 1225
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 22 November 2024
⏱️ 60 minutes
🧾️ Download transcript
Summary
Have we finally discovered the key to youthful energy, longevity, and cellular health?
In this episode, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition and a leading expert on mitochondrial health, cellular regeneration, and anti-aging science. With over 20 years of research, 50 clinical trials, and 15 patents under his belt, Dr. Singh unpacks the groundbreaking science behind Urolithin A, a revolutionary postbiotic that boosts mitochondrial function, enhances immune system resilience, and combats chronic inflammation.
This episode goes beyond cutting-edge science. Dr. Singh reveals practical, real-world strategies to combat “inflammaging”—the chronic, low-grade inflammation that accelerates aging. Learn how fasting, gut health, and mitochondrial boosters like Urolithin A can rejuvenate your cells, fight fatigue, and supercharge your energy, vitality, and longevity.
Here’s what you’ll learn in this episode:
• What Urolithin A is and its role in mitochondrial health and cellular energy production
• How to reverse “inflammaging” and reduce inflammation through nutrition, fasting, and biohacking
• The connection between mitochondrial dysfunction and immune system aging
• Real-life benefits of Urolithin A for energy levels, athletic recovery, skin health, and longevity
• Why mitochondrial support is critical for combating aging and improving overall performance
Resources:
• 2025 Biohacking Conference – https://biohackingconference.com/2025
• Timeline Nutrition - https://www.timeline.com/dave to get 10% off your first order
• Timeline Instagram – https://www.instagram.com/timeline_longevity/
• Dave Asprey’s Website – https://daveasprey.com
• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books
• Danger Coffee – https://dangercoffee.com
• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/
• Dave Asprey’s Linktree – https://linktr.ee/daveasprey
• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com
• Own an Upgrade Labs – https://ownanupgradelabs.com
• Upgrade Labs – https://upgradelabs.com
• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com
Timestamps:
• 00:00 Introduction to Longevity and Mitochondria
• 01:28 The Role of Mitochondria in Immune Health
• 03:36 Understanding Inflammaging and Immune Aging
• 07:47 Measuring Immune Health and Inflammation
• 13:33 Urolithin A: A Mitochondrial Booster
• 16:46 Dosage and Effects of Urolithin A
• 26:11 Urolithin A and Exercise Performance
• 28:31 Urolithin A for Skin Health
• 31:34 Collagen and Aging: The Role of MMPs
• 33:27 Personal Experience with MMPs and Recovery
• 35:04 Measuring MMPs and Their Impact on Longevity
• 36:18 Skin Health and Urolithin A
• 38:39 Exploring Urolithin A’s Broader Benefits
• 40:33 Brain Health and Urolithin A
• 43:33 Combining Supplements for Optimal Health
• 45:54 Omega-3s and Mitochondrial Health
• 46:51 Ketones, MCTs, and Urolithin A
• 54:30 Final Thoughts on MitoPure and Supplementation
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Transcript
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| 0:00.0 | The more CDAT cells you have, the better your longevity health predictor. |
| 0:04.4 | This is the number one intervention that has been shown to sort of reverse a lot of these immune aging decline. |
| 0:10.1 | Mitopure is your cellular health glue or your lubricant. |
| 0:13.6 | Biologists have described nine biological hallmarks of aging. |
| 0:17.1 | If I were to redraw these hallmarks, I would put one in the middle, and that will be... |
| 0:21.6 | You're listening to The Human Upgrade with Dave Asprey. |
| 0:28.9 | Today, we're going to talk about mitochondria. |
| 0:32.3 | Good God. How many times are I going to talk about mitochondria on the show? |
| 0:35.6 | An infinite number of times, one for each |
| 0:37.8 | number of mitochondria in your body. Okay. Not really. But I've become increasingly convinced over the |
| 0:45.0 | last, oh, 25 years of studying my mitochondria and mitochondria in general, that they are at the |
| 0:53.5 | foundation of our interface with reality |
| 0:56.1 | and that they control a lot more in our bodies than we're aware of |
| 1:01.2 | and that science every single day is figuring more and more out. |
| 1:05.2 | Like, oh, let's study the brain. |
| 1:06.6 | Oh, let's study neurons or glial cells. |
| 1:08.3 | Oh, look, there's mitochondria behind them. |
| 1:09.9 | Let's study athletic performance. Oh, look, met's mitochondria behind them. Let's study athletic performance. |
| 1:11.1 | Oh, look, metacondria, sex hormones, metacondria. |
| 1:13.6 | So this is why you keep hearing about them on the human upgrade. |
| 1:17.7 | It's because they matter and because all the different tools you can use |
| 1:21.3 | will make you live longer and make you perform better at whatever it is you want to do as a human |
... |
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