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On Point | Podcast

Unraveling the secrets of the human Y chromosome

On Point | Podcast

WBUR

Talk Show, Daily News, News, Npr, On Point, Daily

4.23.5K Ratings

🗓️ 6 October 2023

⏱️ 49 minutes

🧾️ Download transcript

Summary

For the first time ever, scientists have fully decoded the Y chromosome. Long thought to be the stubby counterpart to the X chromosome, turns out there's far more to the Y than meets the eye.

Transcript

Click on a timestamp to play from that location

0:00.0

Okay, guys, and literally this time I mean guys, guys.

0:05.8

For all the men listening right now, what is the one thing that dwells in each and everyone

0:12.5

of the 30 trillion cells in your body that defines you as the male of the species?

0:20.7

Give you a second or two here to think about it.

0:23.0

Okay, maybe you didn't even need that long because it's kind of an easy question, right?

0:27.8

That's the Y chromosome, of course.

0:30.8

So you'd think that back in 2003 when former president Bill Clinton announced, we're here

0:37.2

to celebrate the completion of the first survey of the entire human genome without a doubt

0:43.5

this is the most important, most wondrous map ever produced by humankind.

0:49.5

Well you would have thought that Clinton meant the entire human genome.

0:55.0

Turns out the map wasn't exactly complete.

0:58.4

More than 10% of human DNA was missing from that first map, notably a detailed, complete

1:05.4

decoding of the Y chromosome, which is kind of odd to me because when you think about

1:11.8

it, the Y is a chromosome in the bodies of 50% of the entire human race.

1:18.0

Well, 20 years later, the Y chromosome is finally getting its due.

1:26.0

This is on point, I'm Magna Chakrabardi.

1:31.7

The Y is the tiniest human chromosome.

1:35.2

It's the short, stubby counterpart to the X chromosome.

1:39.3

Adam Philippi admits it's kind of odd that it hasn't been fully sequenced until now.

1:43.6

He wouldn't expect it to because it's the smallest chromosome.

1:47.1

So you know, why would it take the longest to finish the smallest chromosome?

1:51.8

Philippi is a senior investigator at the National Human Genome Research Institute at the National

...

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