TWiV 970: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 31 December 2022

⏱️ 52 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Modeling the adjustment of COVID-19 response and exit in China (Nature) Canine real-time detection of SARS-CoV-2 infections in mass screening events (BMJ) N95 respirator failure caused by an overlying face mask (ICHE) Airflow in patient rooms may contribute to transmission of severe SARS-CoV-2 (CID) Clinical validation of a T-Cell receptor for identification of recent or prior SARS-CoV-2 infection (CID) Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages (Cell) VV116 vs. Nirmatrelvir–Ritonavir for oral treatment of Covid-19 (NEJM) Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system (ACP) Molnupiravir as early treatment for adults with COVID-19 (The Lancet) Higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support (medRxiv) FDA approves Tocilizumab for the treatment of COVID-19 in hospitalized adults (Roche) Structural brain changes in post-acute COVID-19 patients with olfactory dysfunction (Annals) Paxlovid patient eligbiliity screening checklist (FDA) Persistent post–COVID-19 smell loss association (Science) Epidemiology of long COVID in US adults (CID) Persistent symptoms & sequelae after SARS-CoV-2 infection not requiring hospitalization (OFID) Outpatient treatment of COVID-19 with metformin, ivermectin, and fluvoxamine & the development of long COVID (medRxiv) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 970 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.3	From micro TV, this is twiv this week in virology episode 970 recorded on December 29th,
0:19.9	2022. I'm Vincent Racken yellow and you're listening to the podcast all about viruses. Joining me today
0:27.4	from New York, Daniel Griffin. Hello, everyone. Well, Daniel, that's the end of 2022, our last update
0:36.6	will drop on the 31st, right? It's perfect timing, right? To end end of the year with a clinical
0:45.0	update. It's been quite a year and I would venture to say that next year will also be quite a year,
0:52.4	because viruses don't go anywhere. They really don't, right? I mean, I think we were all getting ready
0:57.2	for a little bit of quiet. I think that was wishful thinking. And as we'll see today, a lot to
1:03.7	share here at the end of 2022. So let's start right off. At the last minute, I changed my quotation
1:11.9	because of some disturbing news. So my quotation, success is no accident. It is hard work, perseverance,
1:20.4	learning, studying, sacrifice, and most of all, love of what you are doing or learning to do.
1:27.9	And that's Palae. So unfortunately, on the day, we're recording. It was announced that Palae died
1:34.8	at age 82. And the world certainly feels diminished without him. He was, well, growing up, I loved
1:42.0	the game of football or soccer, as we call it here in the States. And you know, he was definitely
1:48.5	a figure that I looked up to. And you know, not just a fantastic footballer, but just an individual
1:56.5	who really demonstrated perseverance, hard work. He made a quotation at one point, you know,
2:02.8	about soccer players are not born. Soccer players are created. And really, that's what this
2:07.6	quotation is about. You've got to really work hard to reach a level that he reached.
2:12.4	But let's get right into it. So measles, perhaps people heard the report of the massive measles
2:20.5	outbreak in India. As of November, India had recorded 12,773 cases of measles so far, according to
2:31.6	the WHO. The revival of measles in India, mostly in four large cities, is felt to be happening because
2:39.3	millions of children didn't get vaccinated in 2020, going to the disruptions caused by the COVID-19
	...

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