TWiV 964: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 17 December 2022

⏱️ 42 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Progress toward Poliomyelitis eradication in Afghanistan (CDC) Reduced risk for Mpox after receipt of 1 or 2 Doses of JYNNEOS vaccine (CDC) Reduced airborne transmission of BA.1 Omicron virus in Syrian hamsters (PLOS) Authorized bivalent vaccines for children down to 6 months of age (FDA) Low neutralization of BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine (Nature) Efficacy of antiviral agents against Omicron subvariants BQ.1.1 and XBB (NEJM) Viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir (JAMA) Paxlovid patient eligbiliity screening checklist (FDA) Effectiveness of COVID-19 vaccines in prevention of post–infection conditions (ASHE) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 964 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is Twiv, this week in virology, episode 964 recorded on December 15th,
0:19.6	2022. I'm Vincent Drakenyllo and you're listening to the podcast all about viruses. Joining me today
0:27.6	from Uganda, Daniel Griffin. Hello, everybody. Daniel, where are you this week in Uganda?
0:37.8	So I am very far Western Uganda, very close to the Rwanda border, just south of Lake Edwards. So
0:46.0	if people, people were following the press, this is just very close to where the insurgents came
0:51.6	across, but that was quickly dealt with by the military. So as I told by worried wife, I feel
0:57.6	very comfortable with the Ugandan military walking around in full regalia. So it's an interesting
1:05.0	structure you're in there. It is. This is a German expats ranch. So they have many more cows
1:16.8	than I have. So I'm a bit jealous. And of course I'm wearing a warm jacket because I'm actually
1:21.9	up in the mountains. It's actually cold. I'm in the tropics, but I'm cold. But let me get right
1:26.5	into it. Let's start with our quotation. Perhaps the easiest way of making a town's acquaintance
1:32.6	is to ascertain how the people in it work, how they love, and how they die. And that's Albert
1:38.9	Chemo, the plague. So let's get right into polio. Great stuff out of the CDC recently with the MMWR
1:47.2	progress toward polio myelitis eradication Afghanistan January 2021-September 2022. So this will
1:57.2	get a little complicated. I thought it got a little complicated. So I'll slowly go through this.
2:01.6	Got Vincent right here to help if I get caught up in anything. But just for starters,
2:07.0	Afghanistan and Pakistan are the only countries where wild polio virus type 1 remains endemic.
2:14.5	Two wild polio virus type 1 cases had been reported in 2022 as of September 30th compared with
2:24.1	one case during the same period in 2021. No type 2 circulating vaccine drive polio virus was
2:30.8	reported in 2022 compared with 43 cases in 2021. Now since the political transition in August 2021,
2:40.4	3.5 to 4.5 million previously unreachable children were vaccinated. This is the supplementary
	...

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