TWiV 941: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 1 October 2022

⏱️ 50 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support MicrobeTV with a Spike t-shirt at Vaccinated.US Increase in Acute Respiratory illnesses among children and adolescents (CDC) Estimates of Monkeypox incubation period, generation time, reproduction number (CDC) Rapid increase in suspected SARS-CoV-2 reinfections (CDC) Infection prevention and control recommendations for healthcare providers (CDC) SARS-CoV-2 attack rate in vaccinated and unvaccinated household contacts (CDC) Breakthrough Infection by variants elicited immune response comparable to vaccine (JID) Interval between prior SARS-CoV-2 infection and booster vaccination impacts (CELL) Humoral immunity evasion of BA.4 and BA.5 subvariants (The Lancet) Outpatient Remdesivir prevents severe disease in organ transplant recipients (Am J Transplant) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Effectiveness of Molnupiravir in high risk patients (CID) Update on Long COVID for primary care (BMJ) Distinct symptom pattern emerges for COVID-19 long-haul (Scientific Reports) Dr. Griffin’s treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 941 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.2	From microbe TV, this is TWIV, this week in virology episode 941 recorded on September 29th,
0:20.3	2020, 22. I'm Vincent Racken Yellow and you're listening to the podcast all about viruses.
0:27.0	Joining me today here at the incubator in New York, Daniel Griffin. Hello everyone.
0:34.8	And hello, Vincent. Hello Daniel. How are you? Good to see you here. I am doing well.
0:39.2	Before we get going, let me make two announcements. First, a research assistant
0:43.8	position available at the FDA and Amy Rosenfeld's lab, a focus of that research,
0:49.1	which is at the Center for Biologics and Evaluation and Review at the FDA is to evaluate
0:54.8	mechanisms by which cross species anti-entero virus antibodies may affect virus pathogenesis.
1:01.1	And the research assistant will support work on pecorna viruses like
1:04.5	entero D68, which you've heard about from Daniel, polio virus, which you've also heard about
1:09.2	from Daniel, human rhino viruses, genetic biochemical cell-based studies for understanding multiple
1:15.6	aspects of immune dysfunction associated with virus infection. The individual will carry out
1:20.4	experiments and cell culture and participate in the development of small animal models
1:24.3	for studying multiple aspects of infection, including the tissue-specific cellular immune
1:29.6	response. All the work will be done at BSL-2 conditions. And then of course, help celebrate the
1:36.0	molecule of the year and, which is of course the spike protein of SARS-CoV-2 in support
1:42.0	our work here at micro-obTV by going over to vaccinated.us, buying a t-shirt, and using the promo
1:48.4	code micro-obTV on checkout. The promotion has been extended through October, thanks to Matt for
1:54.3	that. And they're also now including kids t-shirts. So you can get your toddler a spike t-shirt.
2:02.4	How nerdy would that be? Okay, Daniel, it's all yours. I just wish I had a toddler so I could
2:08.4	get them a spike t-shirt. Let us start with our quotation. Why is it, he said, one time at the
	...

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