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This Week in Virology

TWiV 936: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.82.2K Ratings

🗓️ 17 September 2022

⏱️ 52 minutes

🧾️ Download transcript

Summary

In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination, resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Detection of poliovirus in immunosuppressed child (CDC) Severe respiratory illnesses associated with rhinoviruses and/or enteroviruses (CDC) Effects of vaccination and previous Omicron infection in children (NEJM) COVID-19 hospitalizations among vaccinated and unvaccinated adults (JAMA) Effectiveness of vaccines prior to Omicron (IDSA) Nasal iga wanes 9 months after COVID hospitalization (medRxiv) Resistance of Omicron subvariant to antibody neutralization (BioRxiv) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) SARS-CoV-2 spike is associated with post-acute sequelae (IDSA) Impact of vaccination on the risk of developing long-COVID (The Lancet) Contribute to Floating Doctors fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 936 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0

This week in virology, the podcast about viruses, the kind that make you sick.

0:10.4

From micro TV, this is TWIV, this week in virology, episode 936, recorded on September 14th,

0:20.0

2022. I'm Vincent Racken Yellow, and you're listening to the podcast all about viruses.

0:26.5

Joining me today from New York, Daniel Griffin.

0:31.2

Hello, everybody. So I am in New York. Where are you, Vincent?

0:35.4

Today, I am coming to you from Little Rock, Arkansas, the birthplace of the Clinton movement,

0:43.5

if you remember. I remember that. I do. All right. Well, we've got a lot to cover today. We wouldn't

0:50.6

think at this point, but yes, and let me start with my quotation. Franklin's illness gave him

0:56.8

strength and courage he had not had before. He had to think out the fundamentals of living

1:02.8

and learn the greatest of all lessons, infinite patience and never ending persistence.

1:09.5

And that was Eleanor Roosevelt speaking about her husband and his struggle, which is going to

1:16.3

bring us right into what we're going to spend quite a bit of time today. Polio. Now, for those of

1:22.7

you not in New York, for those of you in New York, this week, New York's governor Huckle declared

1:29.2

a polio state of emergency in New York after the virus was detected in a NASA county wastewater

1:37.0

sample. Now, people wonder why it wasn't enough that it was up there in Rockland or Orange,

1:43.4

or even in New York City. Well, I think it's because I live here in NASA County and she knew it

1:48.3

was hidden home. So thank you. Just to be clear, there are likely hundreds, if not thousands of cases

1:56.2

of non-parallytic polio right now in our region. And just before I make it complicated,

2:02.6

it doesn't need to be complicated. Understanding polio, I think, is a little easier than understanding

2:07.8

COVID. I'm sure Vincent might take issue with that, having spent 40 of his years delving into

2:13.6

the complexities of polio. But why do I say there are perhaps thousands of cases of polio out there,

2:21.5

non-parallytic polio? It's because there are three types of polio. People take notes, type one,

...

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