TWiV 932: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 3 September 2022

⏱️ 50 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine effectiveness against Influenza illness in children (CID) Clinical manifestations of infection with Polio (JAMA) Characteristics of deaths among fully vaccinated persons with Coronavirus (CID) Spike protein attenuation of Omicron Variant in lab mice (Cell Reports) Concordance of SARS-CoV-2 results in nasal swabs self-collected vs healthcare collected (JAMA) Probable animal-to-human transmission of Sars-Cov-2 (CID) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) COVID-19–associated hospitalizations among adults during BA.2 variant (CDC) Sars-Cov-2 specific T-cells and antibodies (CID) Nirmatrelvir use and outcomes during the Omicron surge (NEJM) Effectiveness of early Molnupiravir or Nirmatrelvir–Ritonavir in hospitalized patients (The Lancet) Distinguishing features of long COVID (medRxiv) Unexplained post-acute infection syndromes (Nature Med) Contribute to Floating Doctors fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 932 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is TWIV, this week in virology, Episode 932, recorded on September 1st,
0:20.2	2022. I'm Vincent Drakenyllo, and you're listening to the podcast all about viruses.
0:26.7	Joining me today from New York, Daniel Griffin. Hello, everyone. Daniel, you're still enjoying
0:34.4	these updates, even though it's not just COVID anymore? You know, I feel like there's a certain
0:40.0	catharsis. I feel like these updates keep me sane. You know, I have to say like today I went to
0:47.4	the hospital after being in the office, and it's just, I feel like it's nice for me to share
0:57.2	what I'm learning, what I'm seeing. You know, because part of it, I have to say, Vincent,
1:01.7	and I'm sure you experience this as well. Like I read stuff in the newspaper, I'm like,
1:05.6	that's just not what I'm seeing. That's just not what the data shows. Why are they saying that?
1:11.0	And so it's nice, I don't know, I feel like it's nice for me to have this outlet. I'm going to call
1:16.2	it an outlet, and I appreciate all the people that actually come here and spend the time for a
1:21.8	little bit of a deeper dive than just that headline. Great. Glad to hear it.
1:26.0	Well, I will start with my quotation. I started philosophy looking for answers, but along the way,
1:32.0	I came to prize exploring the questions. And that's Kwame Anthony Apaya. And so people will put
1:41.2	a little link in, but this is a modern contemporary philosopher from Sub-Saharan Africa. So I
1:49.9	recommend people check that out. But people may not know. I was a philosophy major as an undergraduate.
1:55.7	How did I end up here? But I think that one of the big things about science is you can't just be
2:03.7	so anxious for those answers. You've got to really, I think appreciate what are the right
2:08.8	questions. What are the questions we can ask? What are the questions we can answer? But I will start
2:14.0	right up front here with California's legislature on Monday, 829 August 29th approved a bill
2:22.8	that would allow regulators to punish doctors for spreading false information about COVID-19
	...

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