TWiV 928: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 20 August 2022

⏱️ 42 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, Pfizer reports additional data on Paxlovid, hospitalization encounters for infection after Paxlovid, a randomized trial of Metformin, Ivermectin, and Fluvoxamine, and readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Response to Polio case in an unvaccinated person in New York (CDC) Human to dog transmission of Monkeypox virus (The Lancet) Tecovirimat for the treatment of Monkeypox (NEJM) Detection of asymptomatic Monkeypox among Belgian men (Nature Medicine) Exposure to disease and precautions (CDC) Risk of infection in healthcare workers (JAMA) Effectiveness of HEPA filters (ASM) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Pfizer reports additional data on PAXLOVID (Pfizer) Hospitalization encounters for infection after PAXLOVID (CDC) Trial for Metformin, Ivermectin, and Fluvoxamine (NEJM) Readmission, post-discharge mortality, recovery among patients (IDSA) Contribute to Floating Doctors fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 928 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.5	From micro TV, this is TWIV, this week in virology, episode 928, recorded on August 18th,
0:20.0	2022. I'm Vincent Racken Yellow, and you're listening to the podcast all about viruses.
0:26.0	Joining me today from New York, Daniel Griffin. Hello everyone, but Vincent, I'm not in New York. I'm
0:35.2	actually in Glasgow. I'm such a creature of habit that I always say New York, but yes, from Glasgow,
0:43.5	Daniel Griffin. Nice to see you, Daniel. No, it's, I had to come down here because apparently the
0:50.0	internet in Edinburgh is not as quick as I would like. So, and I'll start off with a very Scottish
0:57.6	quotation from David Hume from his an inquiry concerning human understanding. In our
1:04.5	reasoning, concerning matter of fact, there are all imaginable degrees of assurance from the
1:10.5	high certainty to the lowest species of moral evidence. A wise man therefore, proportions his
1:17.2	belief to the evidence. I think we're holding humanity to a too high standard, Daniel. It's just
1:24.0	not working. That might be true, but this is my hope is that, you know, I think we actually do
1:30.7	the opposite, like the less certain, the more vehement, the more emotion we bring to a topic,
1:37.6	and then when it's finally very clear cut, we're like, all right, whatever, that's the way it is.
1:41.5	And it really should be the opposite. When we don't know, we should be humble and just say,
1:45.2	you know, we're not sure. We're learning. There's questions out there. This is what we know so far.
1:51.5	We just, we love that, that quick, simple solution to our problem. So, all right, but let us start
1:58.0	with the MMWR. Public health response to a case of paralytic polio-biolitis in an unvaccinated
2:05.6	person and detection of polio virus in wastewater New York, June, dash August, 2020-22.
2:11.8	And I'm going to pull Vincent. We're going to do polio. We're going to do monkeypox. We're going
2:16.8	to do be COVID. We got a lot going here. So, I will start with a little background here.
2:22.7	This report from the MMWR, or in the MMWR, describes the recent case of paralytic polio reported
	...

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