TWiV 910: COVID-19 clinical update #119 with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 18 June 2022

⏱️ 47 minutes

🔗️ Recording | iTunes | RSS

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Summary

In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tixagevimab-Cilgavimab for infection prevention (NEJM) Ivermectin for outpatient infection treatment (medRxiv) Symptom rebound after PAXLOVID treatment (IDSA) Bamlanivimab minimally impacts immune response to vaccination (Sci Transl Med) In-hospital morality among infected patients (IDSA) Casirvimab/Imdevimab & Remdesivir for infected B-cell depleted patients (IDSA) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Residual viral antigen in patients post infection (IDSA) Rheumatic symptoms following infection (IDSA) Contribute to FIMRC fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 910 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.3	From micro TV, this is Twiv this week in virology episode 910 recorded on June 16th, 2022.
0:20.8	I'm Vincent Racken Yellow and you're listening to the podcast all about viruses. Joining me today from
0:27.1	New York, Daniel Griffin. Hello, everyone. Daniel, before we jump into COVID, give us your thoughts on
0:34.7	monkeypox. Is this something that worries you? You know, I guess I should, I'm going to try to
0:39.8	avoid using things like worries me or concern. I mean, just just sort of lay out what we're seeing
0:45.5	and what's going on. So it does look like monkeypox is here in greater numbers than anyone really
0:53.6	appreciate it. And so I think that's the reality. I think as there's growing awareness, there's
0:58.5	going to be a growing number of diagnoses of monkeypox. But I think this is the really important
1:03.7	distinction is what is monkeypox? And I mean, what is it clinically? How does it present?
1:10.4	Right? And I think I shared with you, Vincent actually, and actually I guess I'll share with our
1:16.4	listeners who maybe listened to the ID postcast as well. I was recently involved in helping with a
1:23.2	little girl, three-week-old girl in Ghana who had monkeypox just all over her entire body.
1:30.1	And that's the monkeypox that has plagued, I should say, our people in Western Africa for many,
1:37.1	many years. And it really, it's a devastating, horrible disease in the DRC 10% mortality in
1:43.6	the other variant of Western Africa. It's still, you know, one, two, you know, less than 5%
1:49.2	mortality there. This disease where you're just covered in thesepox. And that's when it's being
1:53.2	recognized and diagnosed. But what we're hearing about now is in many cases, grown men with one or
2:00.5	two postules in their, in their private part areas, you know, resolving nobody's dying in these
2:08.4	hundreds and hundreds of cases. We're hearing about, and so we hear things about, oh, we may be missing
2:12.6	cases. And then I wonder, so is it so horrible if we're missing cases? If that's all it is, if it's a
2:18.4	self-limited infection localized a couple of vesicles, I think that that it's sort of important to
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