TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 21 May 2022

⏱️ 60 minutes

🔗️ Recording | iTunes | RSS

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Summary

In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without vaccination (Nature) EUA for boosters in 5-11 year olds (FDA) Stages of COVID-19 (AIDS Rev) B.1.1.529 attack rate in Australia (JID) Scent dogs (BMJ) Does Omicron affect pets? (CVMBS News) Paxlovid eligibility checklist (FDA) Supratherapeutic tacrolimus with nirmatrelvir/ritonavir (Op For Inf Dis) Is longer Paxlovid needed? (Reuters) How about Veklury? (Gilead) Fluvoxamine declined (FDA) Antigen positivity after isolation (MMWR) Inflammasome activation drives COVID-19 pathology (TWiV 900, Nature) PASC and viral antigen persistence in gut (Gastroenterol) GI symptoms and fecal shedding (Med) Contribute to ASTMH fundraiser at PW Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 901 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is TWIV, this week in virology, episode 901 recorded on May 20th, 2022.
0:20.7	I'm Vincent Racken Yellow and you're listening to the podcast all about viruses,
0:25.1	joining me today from New York, Daniel Griffin. Hello, everyone. I just want to say thank you, Daniel,
0:33.0	for coming to our incubator grand opening last night. It was a lot of fun. You know, it really was.
0:38.3	It was a great time. We had a number of fans who came and expressed their
0:44.0	appreciation for what we do. So that gives me a lot of energy going forward, Daniel.
0:49.8	No, I really appreciate all the, I feel like it's a family, right? The people that listen to
0:56.5	this week in virology, all the other micro podcasts. It's really, it's really, I mean, that's why we do it,
1:01.9	right? We do it because people are listening. I hope we don't just do it because we like, you know,
1:06.4	watching and listening to ourselves. No, no, no, I just love teaching and I know you do as well.
1:11.7	Well, I think that brings us right to my quotation, which is perfect along those lines. Like,
1:16.0	why do we do this? Why are we so passionate? So I will quote Nelson Mandela. Education is the
1:22.0	most powerful weapon you can use to change the world. And that's hopefully what we're doing.
1:27.4	Hopefully we are, we're giving people knowledge where we're educators and hopefully people can
1:33.7	take that education and go for it and change the world. So it's exciting to hopefully be part of that.
1:39.5	And in that theme, let me start off with our update. Where are we? So today as I go through,
1:46.8	I always try to follow sort of the stages of COVID-19. And what I want to do is as we talk about each
1:53.6	stage and some of the new information, some of the new articles and what are we learning, I'm going
1:59.6	to throw a few real cases in there. You know, all the cases I share always are real cases. I don't
2:05.5	just make them up, but I always try to de-identify, I say to protect both the innocent and the guilty.
2:12.4	And at each stage, hopefully that's going to help people understand, like, okay, this is what we know,
	...

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