TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 14 May 2022

⏱️ 56 minutes

🔗️ Recording | iTunes | RSS

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Summary

In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effects of early treatment with Ivermectin (NEJM) Procalcitonin not a reliable biomarker (IDSA) Evaluation of vaccine in children 6 to 11 years (NEJM)) FDA limits use of Janssen vaccine (FDA) Recall of b cell memory on vaccination location (Science Immunology) Persistence screening using sniffer dogs (Journal of Clinical Trials) Tixagevimab/Cilgavimab for treatment of hospitalized patients (Lancet) Infection detection by canine olfaction (OFID) Diagnostic utility to differentiate patients (IDSA) Prevalence of anosmia in pediatric cases (Pediatric Infectious Disease Journal) Risk assessment for public events (University of Texas COVID-19 Modeling Consortium) PAXLOVID patient eligibility screening checklist (FDA) PAXLOVID drug interactions (IDSA) Contribute to ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 899 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is Twiv this week in virology episode 899 recorded on May 12th, 2022.
0:21.6	I'm Vincent Racken Yellow and you're listening to the podcast all about viruses.
0:26.0	Joining me today from New York, Daniel Griffin.
0:30.4	Hello everyone and we'll be talking about COVID. One of those viruses that makes you sick.
0:36.6	You mean SARS-CoV-2? Actually, you're right. Can you believe that?
0:41.9	No, I think that's good. SARS-CoV-2, the virus that makes you sick and when you're sick,
0:46.2	we call it COVID. So the other aspect of this is that people said, oh, I tested positive,
0:55.0	I have COVID. You don't have COVID unless you have symptoms, right?
0:59.5	That's becoming like an interesting issue and I think maybe we'll get into that today.
1:04.0	All right. So all right, let's start off with our quotation.
1:08.0	How poor are they that have not patients? What wound did ever heal, but by degrees?
1:14.9	Thou knowest we work by wit and not by witchcraft and wit depends on dilatory time.
1:21.2	And that's Shakespeare. And nowhere, Shakespeare's got another quotation about sort of rushing.
1:28.7	And I think that involves if you're going to try to assassinate someone. But I think this is more
1:33.0	appropriate if you're trying to gain knowledge if you're trying to move forward.
1:38.6	So that'll be a theme I try to hit on a few times in today's episode.
1:44.8	But I think as everyone knows, the virus is everywhere. There's lots and lots of SARS-CoV-2.
1:50.9	But deaths per day are still sitting at the lowest they have since the pandemic started.
1:57.3	We're still sitting in that two or 250 deaths per day in the United States.
2:02.2	So just keep that in mind. That's the best we've ever done.
2:05.1	I will comment for the week ending 5522.
	...

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