TWiV 890: Looking into a booster crystal ball

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 17 April 2022

⏱️ 115 minutes

🔗️ Recording | iTunes | RSS

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Summary

This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters? (NEJM) Boosting with historical or variant mRNA vaccines (Cell) Vaccination-infection interval determines antibody breadth (Cell Med) Letters read on TWiV 890 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Webb Telescope’s coldest instrument reaches operating temperature Brianne – Video of a CTL killing a tumor cell Rich – Our Unfinished Pandemic (On the Media Podcast) Vincent – Lý Thị Ca Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.5	From microbe TV, this is Twiv this week in virology, episode 890 recorded on April 15th, 2022.
0:21.9	I'm Vincent Drakin Yellow and you're listening to the podcast all about viruses. Joining me today
0:27.3	from Fort Leigh, New Jersey, Dixon de Pommeye. Hello, Vincent and everybody else. And Brianne, I know
0:34.0	that you know this. So I'm just going to say it once. This is the best day of the year so far.
0:40.1	It's got a light breeze, the temperatures in the lower 70s. And here we are all sitting indoors,
0:46.8	wishing we were outdoors. Also joining us from Austin, Texas, rich content. Hi, everybody. The
0:54.1	weather here is boring. It's 75 degrees and overcast and just kind of neck. And from Madison,
1:01.2	New Jersey, Brienne Barker. It is 68 Fahrenheit, 20 Celsius and sunny. Yesterday we were in the 80s.
1:10.6	Wow, yes, that's right. It was sort of shocking, but it is quite lovely out there.
1:15.8	If you're not watching, Brienne has a phenothaline shirt on today. I do. My chemistry colleagues
1:21.0	all like to talk about my phenothaline shirt. It could also be a phenol red, right?
1:25.5	It could be. It could be. It's also the shirt that I wear whenever I take students on field trips,
1:30.8	because they can always find me very easily. It's called Hunter Orange. It's a good idea.
1:36.0	Where do you take them? So we actually go to the Natural History Museum in New York. And so I
1:43.4	take them on the subway and things and they can always find me.
1:46.2	Next time you go, you should stop by here before you go to Penn Station. You could bring them to
1:53.8	the incubator and say, this is where these cool science programs get recorded. All right,
1:59.2	we have a big schedule today. But not so bad because they're relatively straightforward papers
2:05.8	to get through. But I thought we would talk about vaccines, SARS-CoV-2 vaccines and antibodies.
2:12.0	And I was reading these papers and I said, you know, antibodies are not the whole story,
2:17.8	especially neutralizing antibodies, as we've said for many months now. But
	...

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