TWiV 879: Indolent, resistant, and losing our TMPRSS

This Week in Virology

Vincent Racaniello

Virology, Twiv, Pathogen, Virus, Microbe, Vincent, Microbiology, Medicine, Science & Medicine, Infectious, Racaniello, Infection

4.8 • 2.2K Ratings

🗓️ 24 March 2022

⏱️ 99 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2022 Emergence of remdesivir resistance (Nature Comm) How to stall a copy machine (TWiV 819) Omicron altered TMPRSS2 usage (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – NSURP 2022 Kathy – Virology Jobs Rich – 10 Steps from Seed to Cup (Graphic) Alan – Fathoms: The World in The Whale, by Rebecca Giggs Vincent – Worldwaterday.org Listener Picks Jeremy – Archaeology of Light Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is twiv this week in virology episode 879 recorded on March 22nd, 2022.
0:21.3	I'm Vincent Rackenello and you're listening to the podcast all about viruses. Joining me today from
0:27.6	Ann Arbor, Michigan, Kathy Spindler. Hi everybody. Here it's partly cloudy and it's four degrees
0:34.0	Celsius and 49 degrees Fahrenheit from Western Massachusetts, Alan Dove. Good to be here and it is
0:40.6	a blustery spring day west over Air Force bases reporting 52 Fahrenheit 11 Celsius and wind is
0:48.7	northwest at 21 gusting to 28 miles per hour, which is breezy. Is that not far from you that?
0:56.2	Yeah, they're right up the road. They're, they're a, well, they used to be a base for B-52s back in
1:02.5	the Cold War. So they've got the the 9,000 foot runway with the Christmas tree at the end where
1:08.4	they would park the B-52s with the engines running in case they had to go start or war three.
1:14.4	Now they're, they're an air national guard base for C-5s, which are these enormous cargo
1:23.2	planes that go roaring out. What's the Christmas tree mean? It's a, so the taxiway has just
1:30.8	branching parking spaces off it. It looks kind of like a Christmas tree. Isn't it amazing we used
1:36.7	to fly B-52s 24-7, right? Yeah. Whose idea was that the Curtis Lemay or something?
1:42.6	Yeah, it was part of that whole duck and cover era, you know.
1:46.8	Oh my gosh. Also joining us from Madison, New Jersey, Brienne Barker. Hi, great to be here. It's
1:53.8	58 degrees Fahrenheit, 14 C and sunny and also somewhat air conditioned inside.
2:01.8	Some what air? Yes, I'm getting a little chilly. I'm realizing I need to start bringing a sweater.
2:07.1	Is the air on in your place? I think so. Yeah. I just, I'm chilly today.
2:10.8	Near the heat sun, but I have an old steam radiator here, which I have a handle that I turn on and
2:17.4	off when it's too hot or too cold. There's no, the thermostat doesn't do anything.
2:20.9	Oh, fun memories of New York. Yeah. And from Austin, Texas, Rich Condon.
	...

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