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This Week in Virology

TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Microbe, Infection, Twiv, Vincent, Virus, Pathogen, Science & Medicine, Virology, Infectious, Microbiology, Racaniello, Medicine

4.82.2K Ratings

🗓️ 19 March 2022

⏱️ 28 minutes

🧾️ Download transcript

Summary

In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ivermectin did not reduce hospitalizations (Wall St J) Increased hospitalization of children with Omicron (MMWR) Seroconversion of children vs adults (JAMA) Effectiveness of Pfizer-BioNTech vaccine in children (MMWR) High vaccine effectiveness in Finland (medRxiv) Distinct long COVID clinical phenotypes (Open Forum Inf Dis) Estimating excess mortality (Lancet) Contribute to ASTMH fundraiser at PWB Letters read on TWiV 877 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Transcript

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0:00.0

This week in virology, the podcast about viruses, the kind that make you sick.

0:10.4

From microbe TV, this is TWIV, this week in virology, episode 877 recorded on March 18th,

0:19.6

2022. I'm Vincent Racken Yellow, and you're listening to the podcast all about viruses.

0:26.3

Joining me today from Panama, Daniel Griffin. Hello everyone. I apologize for my circumstances. I'm doing

0:36.8

this from a relatively remote part of Panama. So hopefully the audio, the sound quality, the video,

0:44.5

and everything goes well. But let me jump right in. So I will start off with a quotation, which I

0:50.8

actually think is quite appropriate for where I am. And this is a quote from Ronald Ross,

0:58.0

who people may know, who listened to this week in parasitism. The Panama Canal was dug with a

1:05.3

microscope. I just love that, just sort of how important science is in a lot of human ventures.

1:13.0

And I think, unfortunately, we forget that. But yes, I am still down in Panama, but let's jump

1:20.7

right into it. Because actually we have a lot to cover. Case numbers and deaths continue to

1:26.1

decrease in the US as a whole. But as our listeners may have heard, the case numbers have started

1:33.6

to rise globally again. And I will say in New York, the numbers have actually plateaued. They're no

1:38.9

longer dropping. We're actually seeing a little more than 2000 cases a day. We'll see where that

1:46.7

goes. But we did hear this week that the waste water monitoring system is starting to see a rise

1:53.8

in the presence of SARS-CoV-2 RNA in about third of its samples. I'm always getting data a little

2:00.9

bit late. So the March 1 through 10. This is a rise from a low number. But nonetheless, it is a rise.

2:07.6

It is going in the wrong direction. Let's get right into the section that will promise to give us

2:14.0

lots of hate mail. A bit of news starting to be shared about Ivermectin. Initially, I thought this

2:23.1

was the COVID out trial, but no. A little bit of press, actually, a serratory at the Wall Street

2:30.0

Journal, who I've interacted with previously, excellent writer. She put together, I think it's a

2:35.6

pretty good article. And when we get the actual data, as opposed to a Wall Street Journal article,

...

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