TWiV 1333: STING like a nanoparticle, float like HIV

This Week in Virology

Vincent Racaniello

Virus, Pathogen, Infection, Medicine, Microbe, Virology, Infectious, Science & Medicine, Vincent, Twiv, Microbiology, Racaniello

4.8 • 2.2K Ratings

🗓️ 21 June 2026

⏱️ 115 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection. Hosts: VVincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Bundibugyo ebolavirus sitrep (WHO) Ebolavirus and Andes virus with John Dye (TWiV Special) Major research nonhuman primate supplier going out of business (Science) HIV-1 signalling remodels nuclear pores to licence infection (Nature) STING agonist nanoparticles enable mucosal-systemic immunity (Nature Nanoparticles) Timestamps by Jolene Ramsey. Thanks! Picks of the Week Brianne – Otherworldly music albums feature space weather data Rich – Evidence Mapping: Consolidating and summarising available evidence to support the demonstration of effectiveness of developmental vaccines, Australian Living Evidence Collaboration (ALEC) Alan – Holyoke dam fish elevator Vincent – 68 Quadrillion Underground Miles of Fungi Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This week in Virology, the podcast about viruses, the kind that make you sick.
0:10.4	From MicrobTV, this is Twiv. This week in Virology, episode 1333, recorded on June 19th, June 10th, 2026.
0:23.7	I'm Vincent Rackeniello and you're listening to the podcast All About Viruses.
0:28.4	Joining me today from Madison, New Jersey, Brianne Barker.
0:32.6	Hi, it's great to be here.
0:35.0	It is a gorgeous day in Madison, New Jersey, 81 Fahrenheit, 27 Celsius, and just a very nice day.
0:43.2	It's a 28.
0:44.7	28C here.
0:46.3	So if you, if you're into Fahrenheit, that's 82.
0:50.5	And cloudy, also joining us from Austin, Texas, Rich Condit.
0:55.1	Hi, everybody.
0:56.8	So right now it's cool-ish, as things go, 83 degrees.
1:05.0	Overcast, there's a storm system in the vicinity that we, we had a cloud burst, significant one,
1:13.1	not too long ago, which is why it's cool. It's going to go up to 88 by 6 p.m. It's summer
1:19.9	here in Austin, at least close to it. So, it's okay.
1:27.6	Better than not having any weather at all.
1:31.0	What is it?
1:31.8	What's the Mark Twain thing?
1:33.1	Everybody talks about the weather, but nobody does anything about it.
1:37.4	Also, joining us from Western Massachusetts, Alan Dove.
1:41.0	Good to be here.
1:41.8	And in fact, we are doing something about the weather, you know, all the energy we're using.
	...

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