TWiV 1289: Building a better hepatitis B trap

This Week in Virology

Vincent Racaniello

Virology, Twiv, Pathogen, Virus, Microbe, Vincent, Microbiology, Medicine, Science & Medicine, Infectious, Racaniello, Infection

4.8 • 2.2K Ratings

🗓️ 18 January 2026

⏱️ 102 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV explains how the dengue virus protein NS1 alters Aedes aegypti midgut permeability and favors virus dissemination, and achieving a complete hepatitis B virus cure in chronic hepatitis B virus-infected humanized mice by using a capsid assembly modulator. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2026 Positions in Rosenfeld Lab (email) Dengue virus NS1 alters mosquito midgut permeability (mBio) HBV cure with a capsid assembly modulator (Cell Host Microbe) Letters read on TWiV 1289 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – How hibernating bears maintain muscle mass Alan – The flood of Chinese grad students in the 2000s was a boon to US students. Vincent – Feynman Lectures on Physics Listener Picks David – Stewart Cheifet, Host of TV’s ‘Computer Chronicles,’ Dies at 87 Charles – Last Year, and the Year to Come Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This Week in Virology, the podcast about viruses, the kind that make you sick.
0:10.3	From MicrobTV, this is Twiv.
0:13.6	This week in Virology, episode 1287 recorded on January 16th, 2026.
0:22.2	I'm Vincent Rackinello when you're listening to the podcast,
0:25.5	all about viruses.
0:27.6	Joining me today from Western Massachusetts, Alan Dove.
0:31.5	Good to be here.
0:32.3	And here in Western Mass,
0:34.0	it is a balmy 31 Fahrenheit minus one Celsius.
0:39.3	And breezy and a little cloudy and just not a great day to be outdoors.
0:46.7	Here it's one degree Celsius.
0:50.0	When I woke up this morning was minus 5.
0:52.1	Anything under zero Celsius hurts.
0:56.3	You have to really dress warmly.
0:59.9	But I can't compare to where our other guest is, our other host is from Montreal, Canada,
1:07.9	Angela Mingarelli.
1:09.8	Yes, I think I have won the cold battle with this morning.
1:13.8	When we woke up, it was minus 18C.
1:16.1	And it is currently minus 14C, which is, I think, 7 degrees Fahrenheit.
1:21.2	So I would say it hurts when it's below minus 1F.
1:26.1	Because zero for us right now, minus 5C is actually kind of warm,
1:30.6	considering how cold it is.
	...

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