TWiV 1280: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Virus, Science & Medicine, Microbe, Twiv, Racaniello, Infectious, Pathogen, Vincent, Virology, Infection, Medicine, Microbiology

4.8 • 2.2K Ratings

🗓️ 20 December 2025

⏱️ 37 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin and Vincent Racaniello protest Vinjay Prasad, head of CBER FDA Nov memo stating administration of the COVID-19 vaccine resulted in 10 children’s deaths, but are cautiously delighted by the December memo from those in CBER who dispute this data-less claim, how in 31 states pertussis vaccination rates have declined before Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, of clinical outcomes of oseltamivir versus baloxavir for treating influenza infection, number deaths associated with COVID-19 hospitalizations and disease associated economic burden, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, how the German government is committed to research into long COVID and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Industry laments Prasad vaccine memo (Politico) Scoop: FDA vaccine chief’s memo cited 10 pediatric Covid-19 vaccine deaths—but the agency’s own analysis found 0–7 (Inside Medicine) Whooping cough cases soar as vaccination rates drop (NBC News) Marburg Outbreak in Ethiopia: Current Situation (CDC: Marburg Virus Disease) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles(CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Hundreds quarantined as South Carolina measles outbreak accelerates (Washington Post) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) USrespiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) In call with clinicians, CDC recommends flu vaccines widely (CIDRAP) Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) Comparison of clinical outcomes of oseltamivir versus baloxavir in outpatients with influenza: a retrospective cohort analysis (International Journal of Infectious Diseases) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) Effectiveness of 2024–2025 COVID-19 Vaccines in Children in the United States — VISION, August 29, 2024–September 2, 2025 (CDC:MMWR) Mortality following recovery from COVID-19 hospitalization: A long-term cohort study (International Journal of Infectious Diseases) COVID hospitalization tied to 69% higher risk of death for up to 2 years (CIDRAP) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Comparison of work productivity losses in the United States among employees with COVID-19 at high-risk of severe disease who were untreated or treated with nirmatrelvir/ritonavir (Journal of Medical Economics) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulationguidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Long-COVID research just got a big funding boost: will it find new treatments?(Nature) Reaching out to US house representative Letters read on TWiV 1280 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This Week in Virology, the podcast about viruses, the kind that make you sick.
0:10.3	From MicrowTV, this is Twiv. This week in Virology, episode 1280 recorded on December 18th, 2025.
0:21.6	I'm Vincent Rackeniello.
0:23.6	You're listening to the podcast All About Viruses.
0:27.6	Joining me today from New York, Daniel Griffin.
0:31.6	Hello, everyone.
0:34.6	So you're in Germany, you were just telling me Bavaria. I'm in Bavaria. That's the
0:41.1	southern part of Germany. I'm not too far from the Austrian border. Exciting stuff. All right. Well,
0:48.0	we got a lot to talk about today, Vince. And so I went back and forth on quotes.
0:54.9	And finally, I pulled this Robert Frost one.
0:57.3	It's just, I mean, I'm all over the place with so much going on.
1:01.0	But so here we have Robert Frost.
1:03.1	Never be bullied into silence.
1:05.6	Never allow yourself to be made a victim, except no one's definition of your life, define yourself.
1:13.5	Because I think a lot of unfortunate, a lot of our colleagues are being bullied into silence
1:18.9	because of what's going on. We're talking about the anti-science crowd. And this was also
1:25.9	discussed on the Twiv Deepdive, and so this, the headline,
1:30.7	Scoop, FDA vaccine chief's memo cited 10 pediatric COVID-19 vaccine deaths, but the agency's own
1:37.7	analysis found zero to seven. This comes from inside medicine. And this stuff is difficult for me as I'm happy to discuss
1:48.3	things when we actually have the science. And it makes me think of the article we discussed last
1:53.8	week about myocarditis, where you sort of, people just sort of say things. And then you're kind of,
1:58.8	well, where's the science? Where's the evidence?
	...

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