TWiV 1154: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 5 October 2024

⏱️ 39 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rwanda: Marburg virus disease (WHO) Passport required?…..Marburg virus commutes to Germany (CIDRAP) Outbreak of whooping cough/pertussis…..no lifelong immunity following vaccination? (Bloomberg Protection of infants by maternal antibodies against RSV by either vaccination or nirsevimab (MMWR) WHO recommendations for RSV: maternal vaccination and antibody shot (Reuters) Ziresovir for RSV hospitalized infants (NEJM) Crawling to effective anti-RSV countermeasures (NEJM) The $800 million pledge for African mpox response (Reuters) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Doffing your PPE– contact precautions (CID) mRNA vaccination does not elicit durable immune response (Nature Medicine) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Mechanisms of long COVID and therapeutics (Cell) Post hospitalization cognitive deficits and grey matter reduction 1 year after COVID-19 (Nature Medicine) Letters read on TWiV 1154 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This Week in Virology, the Podcast About Viruses, the kind that make you sick. From Micrope TV, this is Twive this weekend virology, episode 1154 recorded on October 3rd,
0:21.5	2024. I'm Vincent Dracken-yellow and you're listening to the
0:25.0	podcast all about viruses. Joining me today from New York, Daniel Griffin.
0:31.6	Hello everyone.
0:34.0	Not Friday, so it's not time for clap on the tie.
0:38.0	So, what do we have on the tie?
0:41.0	It looks kind of like a shepherd's crook. If you were going into the city, this might be easier for you.
0:48.0	Shepherds crook. That should give it away. What really should give it away is if you were going into the city and walking into that room at the incubator and looking at that beautiful bit of art on the wall.
1:01.0	Yeah, it's Shepherds Crook, that's right, Ebola virus.
1:05.9	Yes.
1:07.9	What is a Shepherds Crook?
1:09.1	It's the thing that they use to walk with, like a stick exactly yeah okay and and very soon
1:17.4	people will know why am I wearing a fellow virus bow tie yeah we have a
1:22.2	little outbreak don't we yeah so let's start with our
1:24.6	quotation and and I put this in here because I've had several of my long
1:29.2	COVID patients ask me about this this this particular book, this particular writer. So we'll start off with our
1:36.0	quotation. There are a lot of people who will give money or materials, but very few who will
1:41.8	give time and affection. And this is from Daniel Keys and the book
1:46.5	Flowers for Algernon. And I don't know if our listeners are familiar with that book, but this has come up with a lot of, I'm going to say, my very high-functioning pre-Covid patients who've had that just, you know, devastating cognitive impact that's persisted after an acute COVID.
2:06.6	So just sort of, you know, highlighting just the parallels that they see where they they remember a time when their their mind
2:16.4	worked much better and now they're they're struggling but yes let's get into
2:21.8	Philovirus Marburg.
	...

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