TWiV 1116: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 25 May 2024

⏱️ 47 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin delves highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database and the global phase 3 trail of a novel antiviral, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, reminisces about when available monoclonal antibody therapies were effective, and discusses muscle training/exercise for treatment of PASC/long COVID and the use of RNase for its treatment. For more information about long COVID-19 listen to TWiV 1088. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Clade 2.3.4.4b of highly pathogenic H5N1 in NYC (J Vi) Avian and human influenza A receptors in bovine mammary glands (bioRxiv) Where livestock infected with HPAI live (USDA) Another dairy worker contracted bird flu (NY Times) Reluctance to test for H5N1 (STAT News) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Estimates of hospitalization and deaths prevaccination era (Emerg Inf Dis) Slightly less than half of COVID-19 patients died prevaccination (CIDRAP) How to undress in the time of COVID-19 (CID) Spring vaccineadvice (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (IDSociety) Drug interaction checker (University of Liverpool) Global phase 3 study of ensitrelvir (Shionogi) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Remember when monoclonal antibody therapies worked (JID) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Global clinical study of long COVID-19 (International Journal of Infecitous Diseases) Cardiopulmonary exercises testing of children with long COVID-19 (Pediatric Infectious Disease Journal) Phase 2 trial of RSVL-132 for severe fatigue related to PASC (CID) Muscle training may improve diaphragm muscle weakness 2 years after COVID-19 (American Journal of Respiratory Critical Care Health) Long COVID evidence based review TWiV shout out (TWiV 1088) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1116 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This Week in Virology, the podcast about viruses, the kind that make you sick.
0:07.0	From Microbe TV, this is Twive, this week in Virology, episode 1116, recorded on May 23rd,
0:21.1	2024. I'm Vincent Rachinello and you're listening to the
0:25.2	podcast all about viruses. Joining me today from New York, Daniel Griffin.
0:31.6	Hello everyone.
0:33.0	Okay Daniel, your bow tie is a little blurry.
0:36.0	What do you got on it?
0:37.0	Oh, is it blurry?
0:38.0	Okay, well, you know, hopefully the quality on YouTube will be higher than the quality that you're seeing
0:43.6	Vincent but people will not be surprised when they when they start to listen why I am
0:48.8	today wearing my influenza bow tie with all these little different RNA segments. But let's jump into
0:56.6	it because we've got a lot to cover today. And I'm going to start with a quotation from Frederick Nietzsche, who I am certain I have quoted before.
1:07.0	Actually my, well, dare I say my favorite dog, Zarathustra, was taken from Frederick Nietzsche reference.
1:16.0	But I thought this was appropriate, actually.
1:19.0	And I think maybe it's sort of a caution for our times. The surest way to corrupt the youth is to instruct him to
1:26.5	hold in higher esteem those who think alike than those who think differently.
1:33.0	I love it.
1:34.0	I think we've, with all our social media, right?
1:36.7	We sort of like, I don't want to hear from people who disagree.
1:39.3	I want to hear people that, you know, agree with me.
1:42.0	So maybe our skin needs to be thick again so that we can
1:46.3	we can connect with those shall we say across the aisle those with different opinions
	...

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