TWiV 1057: CMV-based HIV vaccine with Klaus Früh

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 29 October 2023

⏱️ 82 minutes

🔗️ Recording | iTunes | RSS

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Summary

Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells. Host: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Klaus Früh Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) HCMV-based attenuated vaccine platform (Sci Rep) HLA-E-restricted, Gag-specific CD8+ T cells suppress HIV-1 infection (Sci Immunol) RhCMV/SIV vaccine shows long-term efficacy against SIV challenge (Sci Transl Med) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is TWIV, this week in virology, episode 1057 recorded on October 27th, 2023.
0:22.8	I'm Vincent Drakenyllo and you're listening to the podcast all about viruses.
0:29.5	Joining me today from Austin, Texas, Rich Condit. Hi there Vincent.
0:36.3	We've got 86 degrees and partly cloudy. We've had a lot of rain recently, which is welcome,
0:43.8	but it doesn't go any makeup to deficit much, which is substantial. We are entering winter
0:50.8	as a matter of fact next week, they're looking at one night with an overnight low of 32 degrees
0:56.8	and high in the mid 50s. So summer's over. Here in New York, it's 23 and mostly cloudy.
1:05.2	Also joining us today from Madison, New Jersey, Brienne Barker.
1:10.0	Hi guys, great to see you all. They tell me it's fall and getting close to winter,
1:16.1	but the weather here doesn't seem to be aware of that. It's 74 Fahrenheit,
1:21.5	and while my phone says partly cloudy, I see an awful lot of sun at the moment.
1:26.7	So it does not seem like the end of October here at all, but I suppose I'll take it for a couple more days.
1:34.5	So we're at the incubator today, of course, and I have a guest for you. He is from Oregon Health Sciences
1:41.7	University, Klaus, through. Welcome to TWIV.
1:45.6	Very well said. Thank you.
1:48.8	Thank you for having me. It's really pleasure.
1:50.9	Yeah, I practice through a lot because I like to get last names correctly.
1:58.0	Klaus, you're visiting New York, right?
1:59.9	Yeah, that's right. I gave a target at NYU yesterday. I have two friends there. One is Dan
2:06.8	Littman, who I go skiing with once a year in Jackson Hole, and the other one is Ian Moore,
2:12.0	who I play music with for our band, El Petig Lichens, that performs at the International
	...

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