TWiV 1052: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 14 October 2023

⏱️ 42 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Camostat vs Placebo in nonhospitalized adults with mild-to-moderate COVID-19, assessment of the available therapeutic approaches for severe COVID-19, optimal duration of systemic Corticosteroids in COVID-19 treatment, effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients, and the safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic Kidney disease and COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults Antiviral efficacy of molnupiravir vs ritonavir-nirmatrelvir in patients with symptomatic COVID-19 (The Lancet) Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to complications (JAMA) Antibiotic use among hospitalized patients with COVID-19 (OFID) One week of oral Camostat vs placebo in non-hospitalized adults with COVID-19 Assessment of the available therapeutic approaches for severe COVID-19 (Nature) Optimal duration of systemic Corticosteroids in COVID-19 treatment (OFID) Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and in patients with long-COVID syndrome (Nature) Local budesonide therapy in the management of persistent hyposmia in suspected COVID-19 patients (JID) Safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with Kidney disease and COVID-19 Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1052 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.8	From microbe TV, this is TWIV, this week in virology, episode 1552, recorded on October 12,
0:21.2	2023. I'm Vincent Drakenyllo and you're listening to the podcast all about viruses
0:28.9	joining me today here in Boston, Massachusetts. Daniel Griffin. Hello, everyone.
0:35.3	So, Danny, what are we doing in Boston? Well, we are recording at ID Week, Infectious Disease Week
0:40.8	where hundreds of infectious disease specialists, aficionados, people from industry
0:46.9	are gathered to learn about the latest and greatest in infectious disease.
0:51.2	Quite a meeting, really interesting and a good place to do a podcast like a weekly clinical
0:56.8	update. I think that would be great. All right. Well, I'm going to start off with my Boston
1:03.0	appropriate quotation. Those, those who are familiar with Boston, I guess no true Bostonian would
1:10.6	trust a place that was sunny and pleasant all the time, but he gritty, perpetually cold and gloomy
1:16.4	neighborhood, throw in a couple of Dunkin Donuts locations and I'm right at home. And that's
1:21.6	Rick Ryardin. Who is Rick Ryardin? Anyone? Anyone know? He is a writer. He writes the Percy Jackson
1:29.8	books. There are a lot of teenage books. And actually, I have to say they're great, Vincent. His
1:34.8	son, Rick Ryardin's son, both hated history and suffer from dyslexia. And that was his inspiration
1:40.6	to write these books where the heroes, the protagonists of the stories suffer from dyslexia.
1:46.4	And it's a great way to learn about mythology. Okay. So great stuff.
1:50.5	Well, the only thing I disagree with is Dunkin Donuts. I'm not a big fan of Dunkin Donuts.
1:56.3	Well, that's how I know I was in Boston this morning when someone grabbed me coffee. They said,
1:59.4	oh, the line was too long at Starbucks. So I went to Dunkin Donuts where there's one on every corner.
2:03.7	Well, there's a really good place not far from here. I don't remember the name of it.
2:08.0	Okay. Not a chain. It's good. Okay. Sometimes it's best not to look for the chains.
	...

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