TWiV 1032: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 5 August 2023

⏱️ 35 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses predicting COVID-19 incidence using wastewater surveillance data, use of wastewater metrics to track COVID-19 in the US, wastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA counties, association between duration of SARS-CoV-2 positivity and long COVID, rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care, effectiveness of oral Nirmatrelvir/Ritonavir vs. intravenous three-day Remdesivir in preventing progression to severe COVID-19, NIH launching of several phase 2 long-COVID treatment trials. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Predicting COVID-19 incidence using wastewater surveillance data (CDC) Use of wastewater metrics to track COVID-19 in the US (JAMA) Wastewater-based epidemiology predicts COVID-19-induced new hospital admissions (Nature) Association between duration of SARS-CoV-2 positivity and long COVID (JID) Rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care (ACS) Effectiveness of oral Nirmatrelvir/Ritonavir vs. intravenous three-day Remdesivir in preventing COVID-19 progression (Viruses) NIH has launched several phase 2 long-COVID treatment trials (NIH) Fatigue can shatter a person (Atlantic) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1032 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.3	From micro TV, this is TWIV, this week in virology, episode 1032 recorded on August 2nd, 2023.
0:22.4	I'm Vincent Racken, yellow, and you're listening to the podcast, all about viruses.
0:27.4	Joining me today from New York, Daniel Griffin. Hello, everyone. I have an easy question for you,
0:34.3	Daniel. Yeah, I'm really an easy one. That's always like, gets me worried. But please,
0:41.3	is the COVID-19 pandemic over? That's not an easy question, Vincent. And I think as we get into
0:49.1	the sort of, we're going to end up right into the COVID update right after my quotation. But
0:54.3	when I showed up at the hospital on Monday, a quarter of the folks that I saw were hospitalized
0:59.5	due to COVID, not just with COVID, our local positivity rate, 28%. There's a lot of COVID,
1:07.7	there's a lot of people ending up in the hospital. And we'll talk a little bit. I mean,
1:12.9	words matter. I think we may have entered a new phase, but COVID's here to stay. COVID is, yeah.
1:20.8	Can I ask, I'm sorry, COVID's here to stay. That's a good way to interrupt you.
1:27.7	These individuals who are in the hospital, are they older people? Are some of them unvaccinated?
1:34.3	Do they have comorbidities, mainly? So it is, it is mainly, and I think the data shows this
1:41.2	nationally. It's mainly older individuals. It's individuals with comorbidities that we're not
1:46.4	seeing a bunch of folks, healthy young people in their teens or 20s or 30s. What's the biggest
1:55.2	risk factor for a bad outcome with COVID? It's being over the age of 50, over the age of 60,
2:00.6	and then having comorbidities like diabetes, carrying that extra weight, heart disease, hypertension,
2:06.7	cholesterol issues. Okay. And so all these people in the hospital have been vaccinated then. Yeah,
2:12.2	at this point, it is interesting because if you follow the mainstream media, you almost think
2:17.2	there's this huge proportion of our country that is to the point of anti-vax where they're not
2:22.6	getting vaccinated. But the majority of Americans went ahead and got vaccinated. It may have been
	...

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