TWiV 1022: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 8 July 2023

⏱️ 40 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 Infection, effectiveness of the COVID-19 bivalent vaccine, oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults ages 18-50 years, genome-wide association study of long COVID, vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections, and high incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Autochthonous leprosy in the United States (NEJM) Systematic review to identify novel clinical characteristics of Monkeypox (Archives of Virology) Two-year duration of immunity of inactivated poliovirus vaccine (JID) Evaluation of novel oral polio vaccine type 2 SIA impact in a outbreak of vaccine-derived poliovirus in Nigeria (IDSA) Performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 (AIM) Effectiveness of the COVID-19 bivalent vaccine (OFID) Oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults (CID) Genome-wide association study of long COVID (medRxiv) Vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections (JID) High incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID (AJM) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1022 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.5	From microbe TV, this is Tweev, this week in virology, episode 1222 recorded on July 6, 2023.
0:24.0	I'm Vincent Racken-Yellow and you're listening to the podcast all about viruses joining me today from
0:30.2	New York, Daniel Griffin. Hello everyone. So Daniel, we're in the heart of the summer here
0:37.2	and there's not much influenza, there's not much rhino viruses, there's not much COVID also.
0:43.8	There's a little background COVID and I have a few patients in the hospital that I'm taking care
0:48.2	of with COVID, I had a couple of folks when I was just recently at Columbia. So it's at sort of
0:53.2	that low background level at the moment. Is it the same? Would you also see a few flu patients
0:59.4	as well, respiratory, syncystial? Yeah, that's interesting. So we're not seeing any flu patients,
1:04.7	right? We haven't seen RSV. It hasn't locked into the same seasonality. I mean, that's the
1:10.2	prediction. We have yet to see that happen, right? That's the whole idea. But we'll see. I mean,
1:16.2	this is new, right? So this is novel. There I say that. Yes, it's new and we will keep covering it.
1:21.9	Won't we, Daniel? Yeah. Well, I'm glad you bring this up because right now we feel like we're at a
1:26.5	bit of a law, but there's still lots of questions. People are still getting diagnosed. People are still
1:31.7	hopefully taking the right steps to treat it. And there is the predicted increase that we'll see
1:38.9	in a few months. So we'll be here ready to talk about it. But let's get right into it. I don't
1:43.6	know, folks throughout the world are familiar with the 4th of July. That's a big celebration here
1:49.5	in the United States. So this is one of people do all kinds of crazy things to demonstrate their
1:55.3	freedom, including eating food that is soaked in mayonnaise and sitting out in the sun for way
2:00.3	too many hours. But I thought I would pick a quotation from one of my favorites, Elinor,
2:05.9	Roosevelt. I was left to bring that up because my dad actually met her. It was quite impressed
2:10.8	by her. But her quotation with freedom comes responsibility. I feel like Marvel and Spider-Man
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