TWiV 1016: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 17 June 2023

⏱️ 52 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with extended duration Nirmatrelvir/Ritonavir, anemia as a risk factor for disease progression in patients admitted for COVID-19, impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome, post-COVID condition in patients with inflammatory rheumatic diseases, outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months, metformin reduces SARS-CoV-2 in a Phase 3 randomized placebo controlled clinical trial, persistent serum protein signatures define an inflammatory subcategory of long COVID, and the relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Surveillance to track progress toward poliomyelitis eradication (CDC) Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3 (Nature) Evaluation of Oseltamivir to prevent hospitalization in outpatients with Influenza (JAMA) Viral emissions into air and environment after SARS-CoV-2 human challenge (The Lancet) Has COVID-19 threatened routine childhood vaccination (Health Affairs) Successful treatment of COVID-19 with extended duration Nirmatrelvir/Ritonavir (OFID) Anemia as a risk factor for disease progression in patients admitted for COVID-19 (Nature) Impact of fatigue as the determinant of functional limitations among patients with post-COVID-19 syndrome (BMJ) Post-COVID condition in patients with inflammatory rheumatic diseases (The Lancet) Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition (The Lancet) Metformin reduces SARS-CoV-2 in a Phase 3 placebo controlled clinical trial (MedRxiv) Persistent serum protein define an inflammatory subcategory of long COVID (Nature) Relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome (JTM) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1016 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is Twiv this week in virology episode,
0:15.9	one thousand sixteen recorded on June 15th, 2023. I'm Vincent Racken yellow,
0:24.0	and you're listening to the podcast all about viruses joining me today from New York.
0:30.1	Daniel Griffin. Hello, everyone. Big day tomorrow at the FDA, Daniel.
0:37.4	Yes, yes. I think we're hearing some rumors about, you know, so I'll pull off at last time.
0:45.2	I saw him yesterday in Philly. He said they're going to pick a new booster to give everybody over
0:52.2	six months of age. It's interesting. I've heard Paul's and I've heard someone else's take on things.
0:58.8	And I think by the time this drops, we'll have sort of a conclusion. It's probably going to be a
1:04.7	monovalent ex-BB. And yes, and there's going to be this split. People like Paul Offeter are going to say,
1:11.2	so what is this going to offer? And then based on that, who should get it? And other people
1:15.7	going to just say, everyone needs to get it. I'm not getting it, Daniel.
1:20.6	I have three vaccines. I have an infection. I'm good. Let's return to that.
1:27.6	We got to return. So let's first, I am wearing my polio bow tie and people soon understand why.
1:34.7	Also, I'll say right up front, this is one of those episodes that is going to be longer than
1:38.5	21 minutes. So we get to 21. I'll try to give people a heads up. They can pause breaking into
1:43.7	two 21 minute digestible components. But right off my quotation, there are two ways to be fooled.
1:51.9	One is to believe what isn't true. And the other is to refuse to believe what is true.
1:58.0	And that's by Soren Kirkegaard. And let's start off with polio MMWR surveillance to track
2:06.8	progress toward polio myelitis eradication worldwide 2021 through 2022 came out on June 9.
2:16.2	And we've discussed before that the primary means for detecting polio virus is through
2:21.9	acute flaccid paralysis surveillance, you know, waiting till people are paralyzed, which is
	...

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