TRT Dosing And Frequency Breakdown With Dr. Peter Attia
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4.9 • 806 Ratings
🗓️ 25 June 2024
⏱️ 13 minutes
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| 0:00.0 | Any advantage to dosing it once weekly, taking that dose and dividing it by two and doing it twice a week, taking that dose and dividing it by seven and doing it every day? |
| 0:11.1 | Yeah. |
| 0:11.7 | It's, and I don't necessarily know that, like, for example, when patients come to you, I'm sure they're looking for the highest level of optimization, hence why they're with you. |
| 0:20.4 | So maybe it's more reasonable to expect them to pin more frequently. |
| 0:24.0 | I don't say pin, I mean inject. |
| 0:26.0 | But there is a half-life associate with the drug, depending on the ester chosen, typically testosterone |
| 0:32.9 | sypionate will be prescribed, at least in the U.S. |
| 0:36.1 | That's the most prescribed one, which is a half |
| 0:38.2 | life of 10 days, if I recall, off the top of my head. Depends on the person, of course, where it's |
| 0:42.6 | injected, blah, blah, blah, blah. But that half life, you could extrapolate out from that. |
| 0:49.1 | Okay, it's going to take 50 days to achieve steady state serum concentrations in the blood, |
| 0:54.4 | and that's going to look on like a steroid plotter. |
| 0:56.8 | You could check online and see this kind of like, you know, |
| 1:00.1 | spiking until all of a sudden there is the same amount of dropping of the drug |
| 1:04.3 | clearing out of your system. |
| 1:05.2 | You're getting an equal amount of spike backup. |
| 1:07.7 | Like there is no accumulation of drug burden after you've achieved steady state |
| 1:12.5 | serum concentrations. So the advantage to injecting more frequently, and this is going to be |
| 1:19.6 | determined largely by patient adherents more than anything, because some people simply refuse |
| 1:24.9 | to inject even more than I've seen some insane |
| 1:29.3 | insane stuff where people will let themselves drop to literally hypogonatal territory and then |
| 1:35.3 | remember based on their dick not working I'm gonna okay now I take my test but in general once a week |
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