Welcome back to the Real Life Pharmacology podcast. I can't thank you guys enough for all the support,

kind reviews and ratings on iTunes. It's really been overwhelming and I certainly appreciate it,

and I'm going to keep rocking and rolling on the clinical pharmacology education. So today I'm going to talk about Tramidol. Tramidol is a medication

I see used quite a bit, a fair amount. I would classify it within the opioid category.

Its mechanism of action is that binds mu receptors, opioid receptors, and through

CNS, central nervous system inhibition, it can kind of blunt the pain response and pain pathways

that way. When you compare this to something like, let's say, an N-SED, like ibuprofen,

which certainly go back and listen to that podcast about N-ZED pearls,

but when you compare Tramidol and the other opioids,

which I'll cover ahead here on future podcasts,

you've got to remember the difference in that pain pathway.

I think that's important that the opioids basically block the interpretation, the brain

from processing pain signals, while the inseds typically work on the periphery at the site of action in reducing

inflammation and pain mediators at that site of the pain.

So hopefully that kind of gives you a little bit of difference

on how different pain medications work,

particularly insides versus opioids

are a good way to compare and contrast there.

Now with side effects of Tram at all,

brand name is All Tram on that that medication if I didn't say that.

There is another dosage form called Ultraset, which is a combination of Tramidol and Cedaminopin.

I can't say I hardly ever see it utilized, but you may see some providers that do use it occasionally.

...