Welcome to Rosalm Franklin University College of Pharmacy Top 200 Drugs podcast.

This podcast is produced by the pharmacy faculty members to supplement study material for students learning the top 200 drugs.

We're hoping that our real-life clinical

pearls and discussions from practicing pharmacists will help you study for your next drug quiz.

I know participants have any conflicts of interest to disclose. This podcast is for educational purposes only

and is not intended to treat a particular patient. This information should

not be used in lieu of the judgment of a health care provider. This podcast is copyright, Rosalind Franklin

University of Medicine and Science. And now on to the show. Welcome to week seven of the Rosalin Franklin

University Top 200 Dr. Dr. Cain. I'm your co-host, Dr. Cain.

I'm Dr. Weatherton.

And I'm Dr. Patel.

And this week we'll be talking about antifungals and antiviral agents, as well as over-the-counter products

that are also antiviral and antifungal.

So without further ado, we'll go ahead and get started with our first drug, Flucanazol, the brand name is Diflucan.

So Dr. Wetherton, would you want to tell us how these azal antifungals work?

Sure.

The asyl antifungals inhibit an enzyme called 14 alpha demethylase.

That enzyme produces a product called ergosterol, which is important for fungal cell membranes. Without that enzyme,

cell membranes get holes in them and the cells die. It just so happens that fluconazol is one of

the best prototypic drugs that causes drug interactions and that it inhibits metabolism of other

drugs. When we inhibit the metabolism of other drugs, what happens to their

concentration? The concentration of those drugs would increase in the body so you can see

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