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The Model Health Show

TMHS 884: How Your Microbiome Controls Your Mental Health & The Gut-Brain Paradox - With Dr. Steven Gundry

The Model Health Show

Shawn Stevenson

Fitness, Health & Fitness, Motivation, Wellness, Nutrition, Health, Sex, Selfhelp

4.8 • 7.2K Ratings

🗓️ 7 April 2025

⏱️ 62 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Every year, research reveals new information about the microbiome and its critical role in regulating human health. We know that the microbiome can influence everything from immune health to metabolic health. Today, you’re going to learn about the fascinating new science on the microbiome and the brain.

Today’s guest, Dr. Steven Gundry is a bestselling author, the director of the International Heart and Lung Institute, and the founder and director of the Center for Restorative Medicine. His work is focused on curing modern chronic diseases through nutrition. He’s back on The Model Health Show today to share insights from his new book, The Gut-Brain Paradox.

In this conversation, you’re going to learn about how the microbiome can influence brain health and mental health. We’re going to cover leaky gut, the holobiome, and how to restore gut health for better health outcomes. I hope you enjoy this interview with the one and only, Dr. Steven Gundry!

In this episode you’ll discover: 

  • What we know (and what we don’t know) about the brain microbiome.
  • How lipopolysaccharides can wreak havoc on the body.
  • What the holobiome is.
  • The role the gut plays in diseases.
  • How bacteria can communicate.
  • The two ways that calcium can be created in the body.
  • How macrophages, LPS, and neurogenerative diseases are connected.
  • Why gut health can influence mental health.
  • How glyphosate can target happy bacteria in the gut.
  • What percentage of people are vitamin D deficient.
  • The critical role that vitamin D plays in gut health.
  • Why eating prebiotic fiber can transform your health.
  • How to utilize the powerful combination of prebiotic fiber and fermented foods.
  • What lectins are.  

Items mentioned in this episode include: 

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This episode of The Model Health Show is brought to you by Foursigmatic and Organifi.

Visit foursigmatic.com/model to get an exclusive 10% discount on mushroom and adaptogen-packed blends to improve your life. 

Organifi makes nutrition easy and delicious for everyone. Take 20% off your order with the code MODEL at organifi.com/model. 

Transcript

Click on a timestamp to play from that location

0:00.0

You are now listening to The Model Health Show with Sean Stevenson.

0:04.7

For more, visit themodelhealthshow.com.

0:11.5

Today we're going to dive into some new discoveries about the human body.

0:16.1

We're going to be talking about how waste products from bacteria are affecting our brains.

0:21.6

We're going to be talking about the newly discovered microbiome of the human brain.

0:27.6

We're also going to cover how our gut health influences our mental health and so much more.

0:34.6

I love these kinds of conversations because they keep on expanding my own knowledge

0:39.8

base and just blowing my mind. And every time I'm with today's special guest without fail,

0:48.5

he does something to blow my mind. And I'm so grateful for him. He's been a good friend and mentor

0:53.8

for many years now. And not only

0:55.9

does he stay on the cutting edge of research and education, but he is truly a testament now in his

1:03.9

70s to what real longevity can look like. His level of physical fitness, his cognitive function is off the charts and just

1:14.2

hanging out with them you feel like you're just sopping up wisdom he gives off big granddad energy

1:20.5

to say the least and when he was in here today i was actually i was sharing all my problems just like

1:25.3

ah sitting at the at the feet of grandpa and sharing and just that

1:30.4

nurturing energy and you know the wisdom the insight and just the care that he delivers you know again

1:36.6

every time that I get to spend time with him is is just truly amazing so I'm very grateful to be

1:41.7

able to share this conversation with you today now when it comes longevity, there's a certain beverage that I know my special guest loves as well

1:49.5

that is highly, highly associated with a longer lifespan.

1:54.7

A meta-analysis of 40 studies published in the European Journal of Epidemiology revealed that regularly drinking coffee

2:03.9

was associated with the lower risk of death from cardiovascular disease, certain types of cancer,

2:10.2

and all cause mortality. Now, this is just one of many studies affirming the connection

...

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