meta_pixel
Tapesearch Logo
Log in
EM Clerkship

Thrombocytopenia

EM Clerkship

Zack Olson, MD ; Mike Estephan, MD ; Maddie Watts, MD

Health & Fitness, Science, Education, Medicine, Life Sciences

4.9816 Ratings

🗓️ 11 March 2018

⏱️ 9 minutes

🧾️ Download transcript

Summary


Clinical Presentation



* Incidental finding on routing CBC* Petechiae/purpura* Mucosal bleeding* Epistaxis* Gingival bleeding* Hematuria* Vaginal bleeding



5 Major Causes of Thrombocytopenia



* Thrombotic Thrombocytopenic Purpura (TTP)* Clinical presentation (pentad)* Thrombocytopenia* Fever* Microangiopathic hemolytic anemia* “schistocytes”* Neurologic abnormalities* Renal dysfunction* Physiology* Low ADAMTS13 results in impaired vWF breakdown* Widespread “platelet plugs”* Treatment* Plasma exchange* Hemolytic Uremic Syndrome (HUS)* Clinical presentation* Pediatric patient with bloody diarrhea* Renal dysfunction* Thrombocytopenia* Treatment* Supportive care* Heparin Induced Thrombocytopenia (HIT)* Clinical presentation* Recent heparin administration* Acute thrombocytopenia (<150) or 50% decrease in platelets* Treatment* Stop heparin and choose different anticoagulant* Disseminated Intravascular Coagulation (DIC)* Clinical presentation* Patient septic, severe trauma, or otherwise critically ill/injured* Multiple abnormal labs* Increased PT/PTT* Increased D-dimer* Increased fibrinogen degradation products* Treat underlying trigger* Immune/Idiopathic Thrombocytopenic Purpura (ITP)* Common condition* Relatively benign* Treatment* Steroids* Occasionally platelet transfusion* Other causes* HIV* Hepatitis* Heavy alcohol use



Additional Reading



* Thrombocytopenia: An ED Approach (emDOCs)

Transcript

Click on a timestamp to play from that location

0:00.0

Hello, med students. My name is Zach Olson, and thank you for downloading this week's

0:06.1

episode of the EM Clerkship Podcast. Another big topic this week. I got to say, since starting

0:14.6

this podcast, I've been very surprised at how many big topics there actually are. When I was an

0:19.8

intern, I figured chest pain,

0:21.3

shortness of breath, stroke, back pain, abdominal pain, and then other random stuff that is

0:26.3

uncommon. But it turns out that the amount of stuff you need to know to be a good emergency

0:30.3

medicine physician is absolutely just ridiculous. We see random stuff like every shift. That's why I love it. We are literally a jack of all trades.

0:40.5

Right when it seems like the back painters will never end, I'll get somebody with low platelets or

0:46.0

something. And it's just such a mental relief because I hate doing the same thing over and over and

0:51.7

over. It's one of the big reasons why I love my job.

0:56.3

Today, we are talking about thrombocytopenia, which is a big topic, low playlets. Not uncommon.

1:05.6

I've seen this a lot, actually, especially because we're getting CBCs on everybody, which is a completely different

1:12.3

conversation.

1:14.1

You still got to remember your symptoms of thromocytopinia, too, though.

1:18.5

Don't just rely on the lab test.

1:20.3

Platelet issues classically present as the more superficial mucosal type bleeding,

1:26.7

epistaxis, gingerva, maybe GII or bladder or vaginal bleeding,

1:31.6

bleeding to the outside of the body, usually not deep bleeding. Deep is the key word used with

1:38.1

the other coagulation disorders. Deep joint bleeding or deep muscle bleeding. Also remember that with platelet issues, you see those non-blanchual patikia and purpur on the skin.

1:51.3

Just remember those symptoms because you'll definitely see some of that during your clerkship.

1:56.0

But usually we catch this because we get the CBC on everybody.

2:00.2

Today, I want to talk about the big five causes of thrombocitopenia that you need to know.

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Zack Olson, MD ; Mike Estephan, MD ; Maddie Watts, MD, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Zack Olson, MD ; Mike Estephan, MD ; Maddie Watts, MD and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.