This Nobel Prize Discovery Reverses Aging In 72 Hours : 1432
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
4.6 • 7.4K Ratings
🗓️ 15 March 2026
⏱️ 20 minutes
🧾️ Download transcript
Summary
Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.
Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 16-hour fasts aren't enough to reach the deep-cleaning phase. You will learn the exact 3-day protocol to trigger a "Deep Reset," where ketones peak, inflammation falls, and stem cells wake up to rebuild your immune system from scratch.
Join my FREE Fasting Challenge: https://daveasprey.com/fast-this-way-challenge/
Timestamps:
00:00 - The Anti-Aging Switch
01:30 - Chronological vs. Biological Age
02:32 - How Aging Works at the Cellular Level
04:58 - 43 Ways to Upgrade Your Mitochondria
07:37 - What Is Autophagy
09:17 - The Stages of Fasting
10:46 - What Happens During a 3-Day Fast
13:04 - How to Fast Correctly
14:42 - Breaking the Fast
15:58 - The Power of Subtraction
Thank you to our sponsors!
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-Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/
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Transcript
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| 0:00.0 | Imagine waking up with tons of energy, fluid joints, and absolutely no pain in your body. |
| 0:06.6 | What if you knew it was as simple as making a few easy food swaps? |
| 0:10.3 | Oxalates. They're defense chemicals and plant foods, and they slowly wreck your health. |
| 0:14.9 | When you eat them, they steal your minerals and form razor-sharp crystals in your body, |
| 0:19.6 | and those can cause joint pain, muscle |
| 0:21.5 | stiffness, fatigue, even kidney stones. And they stress your mitochondria in multiple studies. Most people |
| 0:27.5 | eat way more oxalates than their body can handle. And they have no idea because you've been |
| 0:31.4 | told all these things are good for you when they're not. So I'm running low ox 30 this January. |
| 0:36.4 | For 30 days, I'll send you one short |
| 0:38.8 | email every morning. You'll learn how to lower your oxalate load step by step without getting up real food or adding stress to your body. You know exactly what to eat, what to swap, and how to support your body as it clears oxalates. By the end of the month, you might feel like a different person, Lighter, clearer, and more energized, and maybe with better skin. |
| 0:56.3 | If you want in, it's a gift. |
| 0:57.9 | Just tap the link in my bio and sign up at Daveaspreet.com. |
| 1:03.4 | How many nights have you stared at the ceiling, counting the hours until morning? |
| 1:08.3 | Maybe you try to sleep supplement, but it knocked you out and left you |
| 1:12.1 | groggy. Like you traded one problem for another. Poor sleep doesn't just make you tired. It kills your |
| 1:17.9 | performance, slows your brain down, and speeds up aging. Kill Switch from Switch supplements solves |
| 1:23.9 | that problem. It works with your biology instead of against it. It contains five |
| 1:29.0 | gut-friendly, extensively researched ingredients like gaba, magnesium glycinate, and tart cherry extract |
| 1:35.7 | to help you fall asleep naturally, stay asleep, and wake up clear. And it's in the form of a |
| 1:40.8 | delicious, sugar-free, no-b-s-hot-coco drink. |
| 1:44.9 | Sleep tracking data proves how well it works. |
| 1:47.5 | People consistently hit 90-plus sleep scores and more than double their REM sleep in only three days with KillSwitch. |
... |
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