Welcome back to another episode of the talk. Today we are back with Professor Serafini and I have a couple more questions for you.

So first and more sciencey question because it relates to what we talked about in our main episode and then I have some more fun questions.

But first of all, I want to talk about this idea of obesity and having this chronic inflammation. The classic

understanding at least for me of obesity was always that it came down to

an excess of calories and because you ate all these extra calories you were

storing more fat and then basically having increased fat stores was what was causing this

increase in inflammation but it sounds like at least as our understanding of obesity

evolves that it's not just about the calories and it has all these other

things that we don't really understand yet and these other pathologies that make it a disease

and not just excess weight. Do we know how the inflammatory state relates to

excess calories or like does it always have to do with eating too much or can there be

inflammatory states if you're not obese just you're eating the wrong foods are you

always an inflammation like how does this two things relate?

Absolutely that's that's a key question.

And I'm glad that you asked me about it

because you know, clearly as you say, you know,

we have the idea that it's correct, know that if we're too much we get obese

inflammation and all the problems but of course obesity is not just

matter of eating too much it could be related to certain alteration in gene expression, many, many

aspects. But the point is that also if you are not obese you can be under inflammatory stress.

That's the point.

Maybe you are only overweight or that's why we have the metabolic syndrome.

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