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No Small Endeavor with Lee C. Camp

The Subtext: The Pitt: What We Get Wrong About Addiction with Erin Calipari

No Small Endeavor with Lee C. Camp

Lee Camp

Philosophy, Society & Culture, Religion & Spirituality

4.8 • 555 Ratings

🗓️ 20 May 2026

⏱️ 48 minutes

🧾️ Download transcript

Summary

Dr. Erin Calipari thinks we're getting a lot wrong about addiction, so she and her lab are working to change that by conducting research that could save lives and destigmatize unhelpful narratives. In this episode, we dig into The Pitt's portrayal of high-functioning addiction and what it gets right that most TV gets wrong.  We sit down with Dr. Erin Calipari to unpack what addiction actually is at the molecular level, and why so much of what society believes about it is not just wrong, but harmful. From the brain's hijacked learning systems to the gender-specific realities of addiction, Dr. Calipari breaks down the gap between cutting-edge science and the policies, stigmas, and drug wars shaping real lives. Things we mentioned in this episode: Follow Erin! Euphoria on HBO Slow Horses on Apple TV Flight of Passage by Rinker Buck Down the Drain by Julia Fox The Handmaid's Tale on Hulu The Pitt on HBO Follow The Subtext: Instagram | Threads | X | YouTube | TikTok Follow Lee: Instagram | Twitter | Lee's Newsletter Follow Savannah: Instagram | Substack Join our Email List: nosmallendeavor.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

Click on a timestamp to play from that location

0:00.0

Hi, Lee. Welcome to our show.

0:02.0

Hello, Savannah. Nice to see you today. How are you feeling about today? I'm feeling great about today. It's a beautiful morning. I was up early again with my cup of coffee on the front porch before watched the sunrise and it was a great morning. Was that like 4.30 before? No, no. The sunrise is late right now. It's like 615. Oh, nice. Yeah.

0:54.9

I ran at 630, and I didn't realize I was so close to the sunrise. Who would have thought? Just get a little earlier. Well, we're sitting this way at the moment together because we have an amazing guest, which I'm so excited about. This is Erin Caliperi. Hi. Hi. Welcome, Erin. I'm here. Welcome. I'm so excited to have you. Erin, I have your bio here, and I'm going to read it in front of you, and you're going to have to just embrace all of it. Okay. Okay. Dr. Cala Perry is the director of the Vanderbilt Center for Addiction Research and an associate professor in the Department of Pharmacology at Vanderbilt University right down the street from us. Her work focuses on understanding the neural circuits. I was about

0:59.6

to say neutral circuits. It's okay. Neural circuits. It's the brain. Hello. That govern

1:05.5

motivated behaviors with particular attention to how these circuits are altered in addiction

1:10.2

in psychiatric disorders.

1:12.5

She is known for her interdisciplinary approach, integrating behavioral, molecular, and circuit-level

1:19.0

data to create comprehensive models of brain function.

1:22.8

Over her career, and I really love this because I'm all about awards, she has won many prestigious

1:27.1

awards,

1:27.9

including the presidential early career award for scientists and engineers, which we love,

1:34.3

from the White House. What did that feel like, by the way? It's actually really funny. So the way

1:40.4

I found out is the White House just like puts out a press release. Okay.

1:48.0

And so somebody texted me and was like, hey, congrats.

1:49.6

And I was like, on what?

1:52.8

And then they just sent me the link to the White House's thing.

1:54.4

And I was like looking at the names.

1:56.2

I was like, oh, I am on there.

1:57.8

That is amazing. And so they basically pick scientists who've kind of made a contribution to different

2:02.6

areas. And so then I was looking for my friends and texting them and being like, hey, just so you

2:06.9

know you're on this list. Did they send you a plaque or anything? They did eventually, but that came

2:11.0

much later. It was just like a random press release in the night. And then in the mail was just like,

...

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