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The Root Cause Medicine Podcast

The Story of 3x4 Nutrigenomic Testing Dr. Yael Joffe

The Root Cause Medicine Podcast

Kate Kresge

Health & Fitness, Alternative Health, 810564, Medicine

4.8581 Ratings

🗓️ 4 March 2025

⏱️ 59 minutes

🧾️ Download transcript

Summary

In today's episode of The Root Cause Medicine Podcast, Dr. Yael Joffe joins Dr. Kate Kresge to discuss her remarkable journey from architecture student to nutrigenomics pioneer, driven by a personal loss that left her searching for answers. You’ll hear us discuss: The role of genetic insights in supporting personalized wellness approaches 3X4 Genetics innovative approach to genetic testing The challenges of bringing genetics into clinical practice How AI might reshape the field Dr. Joffe is a pioneering figure in nutrigenomics and the founder of 3X4 Genetics. Originally from South Africa, she began her career studying architecture before pivoting to dietetics following her grandmother's battle with cancer. Driven to understand the intersection of genetics and nutrition more deeply, she pursued a PhD in genetics while working full-time. Throughout her career, Dr. Joffe has been instrumental in developing nutrigenomic testing methodologies, including the Darwin methodology used by 3X4 Genetics to analyze genetic markers for potential insights in personalized wellness. Additionally, Dr. Joffe is the author of The Power Of Genetics. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

Transcript

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0:00.0

Today on the root cause medicine podcast. I have had the most extraordinary mentors that come into my

0:08.6

life at exactly the time that I need them. It's like a swing. Everything's plateaued. I'm not

0:15.2

learning anything. I don't know where to go next. They come into my life and the relationship, whatever it is, it might be about

0:23.9

knowledge, it might be about having a vision for the future. They pick you up and they swing you

0:28.5

forward into the next phase. And I've had three significant women who came into my life at exactly

0:34.2

the time I needed them. And it's so important in this field of medicine or nutrition

0:39.9

where we're trying to push the boundaries and take the field further, that we always need to be

0:45.0

open, either ourselves mentoring others and saying, hey, I was there once where I didn't know what

0:50.1

I wanted to do, or looking for those extraordinary humans in our life that can take us forward into the next step. Well, hello there. I'm your co-host for today, Dr. Kate Kreske, and we've got an awesome episode for you on Nutrigenomics. We're interviewing the founder of the three-ex-forer genomics test, Dr. Yale Jofi. Now, we've got a really exciting course coming up with her, and I know you're going to want to take it after you listen to this, because the amazing part about this test is it was designed by Dr. Yale, who is a registered dietitian, but also has a PhD in genetics. What was missing in the market several decades ago was a way to take genetic information to know if it was clinically actionable and

1:28.3

then to explain it to your client in a way that allowed them to understand themselves better

1:32.2

and take immediate steps to improve their help based on their unique genetic blueprint. Dr.

1:37.2

Yale designed the test that didn't exist and thousands of people are grateful she did because

1:42.5

they're using it in their practices to help clients get better quickly. So what we'll learn throughout today is that Dr. Yale is hilarious and fun to listen to and a great storyteller. But more importantly, what you're going to learn is that there are 36 actionable insights that come with this test. The report is gamified. So it's actually fun to go through really interesting, really informative. if your clients only have to do it once because it's about their genes, but they're going to use their whole life and refer to it again and again and again. I sat in Dr. Yale's last boot camp, and I learned so much, and it won't surprise you to hear that she's also studied learning and that she's designed this test report to optimize learning for both clients and their practitioners.

2:18.3

So let's dive in.

2:20.3

Before we get started though, I want to talk to you about something that comes up pretty often on this podcast.

2:25.3

And that, of course, is lab testing. You see, testing is one essential way to understand the root cause of an illness.

2:31.3

If you're an integrative or functional medicine practitioner, chances are you're policing a ton of orders with a ton of different labs. The root cause medicine

2:39.7

podcast is created by Rupa Health. Rupa is the best way to order, manage, and track results from

2:45.7

over 30 different labs in one single place for free. Thank goodness. No need to create and log into multiple

2:53.0

portals ever again. If you're a practitioner, make sure you go sign up at rupehealth.com to create

2:58.5

your free account today. Now, let's start the show. Dr. Yale Jofi, welcome to the Rook

3:07.2

Cause Medicine podcast. Thank you, Dr. Kate. I'm, welcome to the Root Cause Medicine podcast.

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