The Science of Keeping the Brain Healthy | Episode 7
Lifespan with Dr. David Sinclair
Lifespan Communications LLC
4.9 • 4.8K Ratings
🗓️ 16 February 2022
⏱️ 62 minutes
🧾️ Download transcript
Summary
In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.
Thank you to our sponsors:
- Athletic Greens - https://athleticgreens.com/sinclair
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- InsideTracker - https://insidetracker.com/sinclair
Our Patreon page: https://www.patreon.com/davidsinclair
Lifespan book: https://amzn.to/3sUqurT
Dr. David Sinclair Social:
Matthew LaPlante's Social:
To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.
Timestamps:
(00:00:00) Introducing Episode Seven: Aging of the Brain
(00:04:39) Thanking the Sponsors
(00:07:38) Ex-differentiation as a Driver of Aging
(00:09:22) The Brain Ages Slowly
(00:14:17) Cognitive Function and Plasticity
(00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins
(00:23:26) Plant-based Diets and B-vitamins
(00:28:32) Homocysteine, Plaque, and Vasculature
(00:32:35) Fatty Acids
(00:35:48) Physical Activity
(00:39:14) Metformin
(00:46:02) NAD Boosters
(00:50:33) Increasing Blood Flor
(00:53:20) Sleep
(00:58:02) Overall Message: Keep your Brain Healthy
(00:58:50) Next Week’s Episode and the Future of Medicine
(01:01:21) Options for Subscription for Support
For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Title Card Photo Credit: Mike Blabac
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
Transcript
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| 0:00.0 | Welcome to the Lifespan Podcast, where we discuss the science of aging and how to be healthier at any stage of life. |
| 0:09.0 | Hi, I'm David Sinclair. I'm a professor at Harvard Medical School in the Department of Genetics, |
| 0:15.0 | and I'm co-director of the Polyff Glenn Center for Biology of Aging Research. |
| 0:19.0 | This podcast is about why we age, and efforts, and things you can do in your daily life, to slow, stop, and even reverse the aging process. |
| 0:28.0 | In the last episode, we talked about the skin, the largest organ in the body. |
| 0:33.0 | We talked about how to stay looking young and feeling good about yourself. |
| 0:37.0 | But today, we're talking about perhaps the most important organ in the body, and that's the brain. |
| 0:42.0 | I'm joined today, and on all episodes so far, at least. |
| 0:46.0 | It's so far at least. |
| 0:48.0 | Yeah, we'll see how you do today. |
| 0:49.0 | We'll see how you do today. |
| 0:50.0 | I don't. |
| 0:51.0 | No, just, I'm enjoying this, it's gone really well. |
| 0:53.0 | Matt and I have been together for years, we wrote the book, Life Span, and he's also my lovely co-host of this podcast series. |
| 0:59.0 | Hey, welcome, Matt. |
| 1:00.0 | I'm really terrified now. |
| 1:02.0 | We're coming up on episode eight, and I'm not going to be here for season two. |
| 1:06.0 | Well, we're going to do a season two, no doubt. |
| 1:09.0 | And I would not do this without you by my side. |
| 1:12.0 | Rob, can we make sure that that part of, like, that I will not do this without you by my side? |
| 1:20.0 | We really want to make sure that that gets broadcast. |
| 1:23.0 | Though I've been known to change my mind. |
... |
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